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Medicine - Ophthalmology | Vitreous - in Health and Disease


in Health and Disease

Sebag, J. (Ed.)

2014, XXVIII, 925 p. 520 illus., 359 illus. in color.

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  • Presents a comprehensive overview of the biochemical composition, molecular organization, morphologic structure, physiology and metabolism of the vitreous body of the eye
  • Highlights both the advances in vitreo-retinal surgery of today with text and video of surgery, along with the non-surgical approaches of the future, namely pharmacologic vitreolysis
  • Clinicians can use this text as a basic science reference manual and researchers will obtain a better understanding of the problems that confront clinicians, helping direct their research to the areas relevant to clinical problems that need development

The vitreous body long has been the most mysterious of all ocular structures, owing perhaps to its seeming simplicity. There have been few concerted, sustained efforts to unravel the mysteries of how vitreous is composed and what role it plays in normal physiology as well as pathology. Over the years, however, many studies have produced important findings concerning vitreous biochemistry, structure, physiology, and pathobiology. Published on the 25th anniversary of Sebag's first book on Vitreous, this second installment is nearly five times longer than its predecessor, reflecting how much has been learned in the past quarter century. This well-constructed compendium not only addresses the most current scientific knowledge, but also reviews clinical perspec­tives in a manner that lends richness to the scope of the book.

 Written by 90 authors, this book has 56 chapters organized into 7 sections: Biochemistry; Anatomy, Development, and Aging; Pathology/Pathobiology; Physiology and Phamacotherapy; Posterior Vitreo-Retinal Surgery; Peripheral Vitreo-Retinal Surgery; and Pharmacologic Vitreolysis. With a foreword by Coleman & Lincoff and an introduction by Wallace Foulds, Sebag's latest tome on vitreous is destined to be the authoritative text for years to come.

Content Level » Professional/practitioner

Keywords » biochemistry - ophthalmology - pathology - pharmacologic vitreolysis - physiology - vitreous

Related subjects » Ophthalmology - Pathology - Surgery

Table of contents 

PREFACE:   J. Sebag

FOREWORD:       D. Jackson Coleman and Harvey Lincoff

INTRODUCTION:      Is your vitreous really necessary?   -  Professor Wallace F Foulds


I.         BIOCHEMISTRY - Professor Paul Bishop, Section Editor

A.  Vitreous Proteins – PB Bishop             

B.  Hyaluronan and other Carbohydrates in the Vitreus– JL Denlinger, EA Balazs

C.  Hereditary Vitreo-Retinopathies – M P Snead, A J Richards          

D.  Vitreous Proteomics and Regression of the Fetal Hyaloid Vasculature

                           – KMP Yee, L P Aiello, MC Madigan, A A Sadun, J Sebag   

E.   Diabetic Vitreopathy – J Gale, L P Aiello, J Sebag        

F.   Vitreous Biochemistry & Artificial Vitreous - S Crafoord, F Ghosh, J Sebag


II.        ANATOMY, DEVELEOPMENT & AGING -  Dr. J. Sebag, Section Editor

            A.        Development and Developmental Disorders of Vitreous                                                                                                       - Z S Kingston, J M Provis, M C Madigan                                                                                         B.        Myopic Vitreopathy – J Gale, Y Ikuno                                                                                              C.            Vitreous Aging & Posterior Vitreous Detachment – K Tozer, M Johnson, J Sebag                          D.            Hyalocytes: Essential Vitreous Cells in Vitreo-Retinal Health & Disease                                                                             – T Kita, T Sakamoto, T Ishibashi                                                                                                      E.            Vitreo-Retinal Interface & Inner Limiting Membrane – W Halfter, E Cunningham, J Sebag           F.         To See the Invisible - the Quest of Imaging Vitreous-J Sebag, RH Silverman, D J Coleman

III.       PATHOLOGY/PATHOBIOLOGY -  Dr. J. Sebag, Section Editor

A.                  Congenital Vascular Vitreo-Retinopathies  - M E Hartnett, R Hobbs

B.                  Anomalous Posterior Vitreous Detachment & Vitreoschisis - J Sebag, M Niemeyer, MJ Koss

C.                  Pathology of Vitreo-Maculopathies  - A Gandorfer, R Schumann, C Haritoglou, A Kampik

D.                 Vitreo-Macular Adhesion/Traction & Macular Holes - Pseudo, Lamellar & Full-Thickness                                                                         -  M Englander, JS Duker, PK Kaiser

E.                  Vitreo-Papillary Adhesion and Traction - MY Wang, AA Sadun, J Sebag

F.                  Vitreous in the Pathobiology of Macular Pucker – K Tozer, J Sebag                       

G.                  Vitreous in Age-related Macular Degeneration – I Krebs, C Glittenberg, S Binder 

H.                 Peripheral Vitreo-Retinal Pathology - J Sebag, S Dunker, WR Green

I.                    Role of Vitreous in the Pathogenesis of Retinal Detachment –W Foulds   

J.                    Cell Proliferation at the Vitreo-Retinal Interface in Proliferative Vitreo-Retinopathy and Related             Disorders         –     S Mehta, R Zhang, HE Grossniklaus

K.                  Vitreous in Retino-Vascular Diseases and Diabetic Macular Edema – GE Lang     

L.                  Proliferative Diabetic Vitreo-Retinopathy –P Kroll, EB Rodrigues, CH Meyer

IV.       PHYSIOLOGY & PHARMACOTHERAPY - Professor Einar Stefansson, Section Editor

A.    Vitreous Physiology – E Stefánsson                    

B.     Oxygen in Vitreo-Retinal Physiology and Pathology - N Hollekamp, D Beebe, Y B Shui

C.     Vitreous and Iris Neovascularization - D McLeod

D.    Physiology of Accommodation & Role of Vitreous  - D J Coleman & R H Silverman & H Lloyd  

E.     Principles and Practice of Intravitreal Application of Drugs – P Lin, S Mehda, E deJuan         

F.      Pharmacotherapy of Proliferative Vitreo-Retinopathy – P J Banerjee, D G Charteris, D Wong

G.      (SiO, PFCs) - I Y Wong, N Cheung, D Wong      


A.        Posterior Vitreo-Retinal Surgery - Professor Susanne Binder, Section Editor

1.    Age-Related Macular Degeneration Surgery - S Binder, L P Chong          

2.    Vitreo-Maculopathy Surgery – M Figueroa, I Contreras                      

3.    Chromodissection in Vitreo-Retinal Surgery – C Haritoglou, A Gandorfer A Kampik

4.    Macular Hole & Macular Pucker Surgery with Special Emphasis on Re-Operations –

                                                B Pan, K M P Yee, F N Ross-Cisneros, A A Sadun, J Sebag

5.    Surgery of Diabetic Vitreo-Retinopathy & Diabetic Macular Edema -

                                                S Brunner & S Binder   

6.   Vitreous Surgery of Arterial and Venous Retino-Vascular Diseases  –  J Garcia-Arumi &

S Binder, M Leila,  M Victori



B.        Peripheral Vitreo-Retinal Surgery  - Dr. Lawrence P. Chong, Section Editor

1.         The History of Vitrectomy Instrumentation – J M Parel

2.         Modern Vitrectomy Cutters – L P Chong     

3.         The Future of Vitrectomy – J P Hubschman, S U Shah, V B Voleti

4.         Prophylaxis and Cure of Retinal Detachment – C P Wilkinson  

5.         Management of Proliferative Vitreo-Retinopathy- A. N. Mehta & G. W. Abrams  

6.         Retinectomy in Recalcitrant Retinal Detachments – L. P. Chong       

7.         Pneumatic Retinopexy – K M P Yee and J Sebag    

8.         Floaters and Vision - Current Concepts and Management Paradigms

                        L. C. Huang, K M P Yee, C A Wa, A A Sadun, J Sebag

9.         Rare Indications for Vitrectomy: Tumor Excision, Optic Nerve Pits, Malignant

                        Glaucoma -                               L P Chong                                                       



VI.       PHARMACOLOGIC VITREOLYSIS -  Dr. J. Sebag, Section Editor

A.                Pharmacologic Vitreolysis -  J Sebag 

B.                 The History of Pharmacologic Vitreolysis -  W S Foulds      

C.                 Pharmacologic Vitreolysis with Tissue Plasminogen Activator – P Kroll & H Hesse

D.                Pharmacologic Vitreolysis with Plasmin                                                                                               1.             Basic Science Experiments - Th Verstraeten                                                                           2.            Clinical Studies - H Terasaki & T Asami       

E.                 Pharmacologic Vitreolysis with Ocriplasmin                                                                                                     1.         Basic Science Studies - M deSmet & B Jonkcx                                                        2.             Clinical Studies - P Stalmans    

F.                  Hyaluronidase as a Vitreous Liquefactant -  M deSmet, L Grillone             

G.                Pharmacologic Vitreolysis with Dispase (Vitreolysin™)                                                                   - T H Tezel, L. Del Priore, H J Kaplan

H.                Chondroitinase as a Vitreous Interfactant                                                                                          -  Vitreous Dis-insertion in the Human - S R Russell, G S Hageman  

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