Molecular Basis of Breast Cancer

1. Front Matter

   Pages I-XIV

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2. Epidemiological Considerations in Breast Cancer

   • Jose Russo, Irma H. Russo

   Pages 1-9

3. The Breast as a Developing Organ

   • Jose Russo, Irma H. Russo

   Pages 11-48

4. Endocrine Control of Breast Development

   • Jose Russo, Irma H. Russo

   Pages 49-88

5. The Role of Estrogen in Breast Cancer

   • Jose Russo, Irma H. Russo

   Pages 89-135

6. Pathogenesis of Breast Cancer

   • Jose Russo, Irma H. Russo

   Pages 137-180

7. Animal Models for Human Breast Cancer

   • Jose Russo, Irma H. Russo

   Pages 181-226

8. In Vitro Models for Human Breast Cancer

   • Jose Russo, Irma H. Russo

   Pages 227-280

9. Genomic Basis of Breast Cancer

   • Jose Russo, Irma H. Russo

   Pages 281-316

10. Preventive Strategies in Breast Cancer

    • Jose Russo, Irma H. Russo

    Pages 317-378

11. The New Paradigm in Breast Cancer Prevention

    • Jose Russo, Irma H. Russo

    Pages 379-438

12. Back Matter

    Pages 439-448

    PDF

book, whose goal is to comprehensively review in ten During the past 30 years we have witnessed the emer­ chapters the fundamental knowledge on breast can­ gence of new disciplines whose contribution to the understanding of the biology of breast cancer have cer. The opening chapter links epidemiology, influ­ been enormous. Advances in the field of steroid hor­ ence of geographic and environmental exposures on mone nuclear receptors, which control the expression cancer incidence to the development of the organ and of genetic programs involved in cellular processes its role in cancer initiation. Central to this approach that are essential for normal and aberrant cell is the endocrine control of breast development, the growth, have been major contributors to the therapy relationship of cell proliferation with the presence of and prevention of hormone-dependent cancers. The steroid hormone receptors in the breast epithelium, and finally the importance of full differentiation as a discoveries of the association of hereditary breast cancers with mutations in the BRCAl and BRCA2 tool for protecting the breast from developing cancer. genes, and the concept that they essentially represent Reported are studies of the pathogenesis of breast a continuum of mutations with different degrees of cancer that have elucidated the site of origin of breast penetrance within given families, have added consid­ cancer and have been validated by in vitro experi­ erable understanding to the molecular basis of breast mentation.

• Breast
• Differentiation
• Treatment
• cancer
• pathogenesis
• prevention

From the reviews:

"This book provides the scientific basis for a new paradigm according to which breast cancer prevention and treatment should be developed. The book is unique in that it is based on an understanding of the developmental pattern of the breast in rodents and humans." (Biomedicine & Pharmacotherapy, Vol. 58, 2004)

"This is a comprehensive and detailed textbook which covers all the fundamental areas of knowledge on breast cancer. … This text provides an excellent reference book for anyone involved in this field … . For those wanting an in-depth knowledge of this rapidly expanding field, this is easy to read and tackles complex theories very successfully with excellent illustrations to all chapters." (Erika Denton, RAD Magazine, September, 2004)

"Molecular Basis of Breast Cancer provides a window through which to view some future strategies in the prevention of breast cancer. This richly illustrated book has a unique focus and original perspective. … The broad summary of the scientific literature on this area of research strongly adds value to the book." (Robert B. Dickson, The New England Journal of Medicine, Issue 9, 2004)

• Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, USA

  Jose Russo, Irma H. Russo

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