Locoregional Tumor Therapy

1. Front Matter

   Pages i-vi

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2. Introduction

   • René Adam

   Pages 1-2

3. Basics of Regional Tumor Therapies

   1. Front Matter

      Pages 3-3

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   2. Pharmacokinetic Aspects of Regional Tumor Therapy

      • Martin Czejka, Katharina Schüller

      Pages 5-17

   3. Embolization Materials, Catheters, and Intra-arterial Ports

      • Geert A. Maleux

      Pages 19-28

4. Intra-arterial Therapies: Liver

   1. Front Matter

      Pages 29-29

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   2. HCC

      • Franco Orsi

      Pages 31-54

   3. CRC Liver Metastases

      • M. Peeters

      Pages 55-72

   4. Liver Metastases of Neuroendocrine Tumors and CCC

      • Thomas Ettrich, Thomas Seufferlein

      Pages 73-88

   5. Liver Metastases of Other Indications

      • Michel Ducreux

      Pages 89-106

5. Intra-arterial Therapies: Lung, Head and Neck

   1. Front Matter

      Pages 107-107

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   2. Chemoembolization of Lung Tumors

      • Thomas J. Vogl

      Pages 109-124

   3. Head and Neck

      • Adorján F. Kovács

      Pages 125-138

6. Thermoablation

   1. Front Matter

      Pages 139-139

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   2. Radiofrequency Ablation for Treating Malignant Tumors to the Liver

      • Andreas H. Mahnken, Thierry de Baère

      Pages 141-154

   3. Radiofrequency Ablation for Treating Malignant Tumors to the Lungs

      • Andreas H. Mahnken, Thierry de Baère

      Pages 155-161

Recent years have witnessed a renaissance in the use of locoregional tumor therapy as part of a multimodal therapeutic approach to a variety of solid tumors, and attempts are underway to define its value in the overall therapeutic strategy for individual tumor entities. This flourishing of interest in locoregional tumor therapy derives from a series of important new developments concerning methodology, drug treatments, and instrumentation. The resulting approaches include not only optimized locoregional chemotherapy and chemoembolization for hepatocellular carcinoma and other tumors, but also other “targeted” therapies such as stereotactic radiosurgery, radiofrequency ablation, intra-arterial administration of radiopharmaceuticals, and complex new methods of chemoembolization of liver metastases involving the use of multiagent chemotherapy in combination with targeted drugs, drug-eluting beads/microspheres, or nanoparticles. In addition, intraperitoneal and intrapleural therapies, e.g., cytoreduction plus hyperthermic intraperitoneal chemotherapy, are now a standard element of the strategy for a range of tumors. It is vital that practitioners have the necessary expertise in the use of these locoregional treatment methods and understand how to combine them optimally with modern systemic therapies. With that goal in mind, this book presents, in condensed form, the clinical results achieved using various locoregional tumor therapies. In so doing, it will allow the reader to rapidly retrieve the information on indications and effectiveness that is required for optimal integration of these highly effective therapies into modern, yet more complex treatment strategies.

• HCC
• Intraarterial Chemotherapy
• Liver Metastasis
• TACE
• Thermoablation
• surgical oncology

• Department of Oncology, University Hospital Gasthuisberg Leuven Cancer Institute, Leuven, Belgium

  Eric Van Cutsem

• Department of Diagostic Radiology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany

  Thomas J. Vogl

• Department of Radiology, European Institute of Oncology, Milano, Italy

  Franco Orsi

• Department of Medical Oncology, IRCCS Ospedale San Martino IST, Genova, Italy

  Alberto Sobrero

Policies and ethics