RNA and Cancer

1. Front Matter

   Pages i-xiii

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2. Coupling Between Transcription and Alternative Splicing

   • Ignacio E. Schor, Luciana I. Gómez Acuña, Alberto R. Kornblihtt

   Pages 1-24

3. Detection of Alternatively Spliced or Processed RNAs in Cancer Using Oligonucleotide Microarray

   • Marieta Gencheva, Lixin Yang, Gong-Biao Lin, Ren-Jang Lin

   Pages 25-40

4. Cancer-Associated Perturbations in Alternative Pre-messenger RNA Splicing

   • Lulzim Shkreta, Brendan Bell, Timothée Revil, Julian P. Venables, Panagiotis Prinos, Sherif Abou Elela et al.

   Pages 41-94

5. Alternative Splicing of Tumor Suppressors and Oncogenes

   • Claudia Ghigna, Silvano Riva, Giuseppe Biamonti

   Pages 95-117

6. MicroRNAs in Cancer

   • Jianzhong Jeff Xi

   Pages 119-137

7. The Perinucleolar Compartment: RNA Metabolism and Cancer

   • John T. Norton, Sui Huang

   Pages 139-152

8. Regulation of ARE-mRNA Stability by Cellular Signaling: Implications for Human Cancer

   • Christian Kroun Damgaard, Jens Lykke-Andersen

   Pages 153-180

9. Alternative Pre-mRNA Splicing, Cell Death, and Cancer

   • Kong Ruirui, Payal Ray, Mengxue Yang, Pushuai Wen, Li Zhu, Jianghong Liu et al.

   Pages 181-212

10. Oligonucleotide Therapeutics in Cancer

    • Jing Wan, John A. Bauman, Maria Anna Graziewicz, Peter Sazani, Ryszard Kole

    Pages 213-233

11. Clinical Perspective on Chemo-Resistance and the Role of RNA Processing

    • Nancy L. Krett, Shuo Ma, Steven T. Rosen

    Pages 235-245

Accumulating evidence supports the role of defects in post-transcriptional gene regulation in the development of cancer. RNA and Cancer examines the recent advances in our understanding of post-transcriptional gene regulation, especially RNA processing and its role in cancer development and treatment. A particular focus is mRNA splicing, but other topics such as microRNAs, mRNA stability, the perinucleolar compartment, and oligonucleotide therapeutics are also covered in detail. All chapters have been written by internationally renowned experts. The book is intended for all with an interest in gene regulation and cancer biology, and especially for those not directly working on RNA biology, including clinicians and medical students. It is hoped that it will stimulate further innovative research collaborations between RNA biologists and cancer researchers to the benefit of patients.

• Alternative splicing
• Cell death
• Imaging
• Microarray
• Tumor

• Dept. of Neurology, Robert H. Lurie Cancer Center Center for Genetic Medicine, Chicago, USA

  Jane Y. Wu

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