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Medicine - Oncology & Hematology | Small Molecules in Oncology

Small Molecules in Oncology

Martens, Uwe M. (Ed.)

2010, XVI, 238 p.

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  • Provides a broad overview of the small molecules currently used for the treatment of malignant diseases
  • Discusses interesting novel compounds that are in the process of clinical development to combat cancer
  • Written by acknowledged experts

Extensive research into the molecular mechanisms of cancer disease has heralded a new age of targeted therapy. In malignant cells, key proteins that are crucial to tumor growth and survival are now being targeted directly with rationally designed inhibitors. Apart from monoclonal antibodies, small molecule therapeutics such as oncogenic protein kinase inhibitors are attracting a vast amount of investigational attention. This textbook, written by acknowledged experts, provides a broad overview of the small molecules currently used for the treatment of malignant diseases and discusses interesting novel compounds that are in the process of clinical development to combat cancer.

Content Level » Professional/practitioner

Keywords » Molecular mechanisms of cancer - Oncogenic protein kinase inhibitors - Targeted therapy - Treatment of malignant diseases - tumor growth

Related subjects » Cancer Research - Internal Medicine - Oncology & Hematology

Table of contents 

Protein kinase inhibitors.- Imatinib Mesylate.- Erlotinib.- Axitinib (AG-013736).- Lapatinib.- Sorafenib.- Sunitinib.- Dasatinib.- Nilotinib.- Bosutinib.- Epigenetic modifiers.- Decitabine.- 5-Azacytidine/Azacitidine.- Cell cycle inhibitors.- Bortezomib.- Temsirolimus.- Danusertib (formerly PHA-739358) – A Novel Combined Pan-Aurora Kinases and Third Generation Bcr-Abl Tyrosine Kinase Inhibitor.- BI_2536 - Targeting the Mitotic Kinase Polo-Like Kinase 1 (Plk1).- Other novel agents.- Imetelstat (GRN163L) - Telomerase-Based Cancer Therapy.- GDC-0449 - Targeting the Hedgehog Signaling Pathway.

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