Pediatric Liver Tumors

1. Front Matter

   Pages i-xii

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2. Introduction

   • Arthur Zimmermann, Giorgio Perilongo

   Pages 1-1

3. Historical Background

   • Jack Plaschkes

   Pages 3-14

4. Epidemiology of Pediatric Liver Tumors

   • Jillian M. Birch

   Pages 15-26

5. Molecular Aspects of Hepatoblastoma

   • Roland Kappler, Dietrich von Schweinitz

   Pages 27-42

6. Ontogenetic Aspects of Liver Tumors

   • Arthur Zimmermann

   Pages 43-51

7. Translational Investigations of Liver Tumors: Sampling Strategies and Banking

   • Michael Grotzer, Tarek Shalaby

   Pages 53-58

8. Clinical Presentation and Diagnosis

   • Laurence Brugières

   Pages 59-64

9. Imaging and Staging of Pediatric Liver Tumors

   • Derek J. Roebuck

   Pages 65-82

10. Pathology of Pediatric Liver Tumors

    • Arthur Zimmermann, Dolores Lopez-Terrada

    Pages 83-112

11. Surgical Treatment

    • Piotr Czauderna, Dietrich von Schweinitz

    Pages 113-131

12. Liver Transplantation for Unresectable Liver Tumors in Children

    • Rebecka L. Meyers, Jean-Bernard Otte

    Pages 133-152

13. Chemotherapy for Childhood Hepatoblastoma and Hepatocellular Carcinoma

    • Giorgio Perilongo, Bruce Morland, Marcio Malogolowkin

    Pages 153-163

14. Salvage Strategies

    • Jozsef Zsiros, Laurence Brugières

    Pages 165-176

15. Alternative Approaches for Treatment

    • Derek J. Roebuck

    Pages 177-188

16. Supportive Therapy and Toxicity

    • Penelope Brock, Gill Levitt

    Pages 189-199

17. Challenges and Opportunities of International Therapeutic Trials

    • Rudolf Maibach

    Pages 201-207

18. Tumors Other than Hepatoblastoma and Hepatocellular Carcinoma

    • Gianni Bisogno, Arthur Zimmermann

    Pages 209-221

19. Future Prospective

    • Giorgio Perilongo, Arthur Zimmermann

    Pages 223-225

20. Back Matter

    Pages 227-231

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The field of liver tumors in children has seen tremendous therapeutic advances over recent years. This has been achieved through a much better understanding of the biology of disease, improved diagnostic procedures, refined methods of pretreatment tumor staging, the implementation of highly efficient chemotherapy and surgery, detailed monitoring of toxicity, and careful follow-up strategies. International controlled trials have played a key role in these advances, and many leading figures in the trials are among the editors and authors of this book. Their principal goal in Hepatic Tumors in Children is to provide the reader with a complete update on this complex and rapidly evolving field. All aspects of an impressive success story are covered, disclosing how the outcome of a previously devastating disease has been so dramatically improved. This book will prove essential reading for all who are involved in the care of children with liver tumors.

• Cancer
• Children
• Hepatic Tumors
• Liver

From the reviews:

“This slender but tightly packed book is essentially a report on the current status of surgical and chemotherapeutic treatment of childhood liver tumors, based on the most current data from the American and European collaborative treatment groups. … Pediatric surgeons working in specialized tumor surgery settings, with the Children’s Oncology Group, or who support research activities in liver tumors will find this book invaluable. … It will stand as a thorough and quick reference in the topic as currently understood, diagnosed, and treated.” (Robert M. Arensman, Doody’s Review Services, September, 2011)

• Inst. Pathologie, Universität Bern, Bern, Switzerland

  Arthur Zimmermann

• Dipto. Pediatria, Unità di Oncoematologia Pediatrica, Università di Padova, Padova, Italy

  Giorgio Perilongo

Prof.Dr.med.em Arthur Zimmermann graduated in Medicine at the University of Berne, Switzerland. He attended the local Pathology Residency Program, followed by several years of experipmental basic research in the fields of cancer cell cycle mutants and mechanisms of leukocyte and cancer cell motility. As chief of staff and then head of the division of surgical pathology at the University of Berne he specialized in hepatobiliary and pancreatic tumor pathology, where he became the author and coauthor of more than 500 publications. Until July 2009, Prof. Zimmermann was Acting Director of the Institute of Pathology of the University of Berne. As an expert in pediatric liver tumors he is an international consultant and holds the Pathology Review Center for the International Childhood Liver Tumor Study Group ( SIOPEL ). Prof. Giorgio Perilongo graduated in Medicine in 1980 at the University of Padua, Italy; he then attended the local Pediatric Residency program for then completing his post-graduate education with a fellowship in Hematology-Oncology first and in Neuro-Oncology thereafter at the Children’s Hospital of Philadelphia. Presently he is the Chairman of the Department of Pediatrics of the University Hospital in Padua. He was among the founders of the International Childhood Liver Tumor Study Groups (otherwise known as SIOPEL group), the international cooperative research group on childhood liver tumors based in Europe conceived within the umbrella of the International Society of Pediatric Oncology. Within this group is has and he is still playing a very active role. He chaired a series of clinical trials already published in the main international scientific journals.

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