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"Metastatic Bone Disease: Fundamental and Clinical Aspects"
is an expanded version of a workshop on bone metastases
which was held in Heidelberg, Germany, in April 1993. Bone
metastases very often develop from malignant tumors and lead
to complications which considerably diminish the quality of
life of the patient. Bone pain, pathological fractures, and
hypercalcemic syndrome should be recognized and treated ear-
ly, so as to prevent any further morbidity and immobilizati-
on. Antiosteolytic substances such as biophosphonate can
supplement the established palliative and supportive thera-
Highly qualified basic researchers and clinicians in
pathophysiology, diagnosis, and treatment of metastatic bone
disease have contributed to this book, providing a good
overview ofpresent knowledge and research. The book will be
of interest not only to specialists, but also to any physi-
cian interested in oncology.
Historical Remarks on Metastasis and Metastatic Bone Disease.- Nature of Metastatic Bone Disease.- Incidence and Distribution of Bone Metastases.- Detection and Characterization of Tumor Cells in Bone Marrow of Patients with Primary Breast Cancer.- Normal Bone Remodeling and Metastatic Bone Disease.- Morphological Findings in Bone Metastasis, Tumorosteopathy and Antiosteolytic Therapy.- Mechanisms of Osteolytic Bone Destruction.- Diagnosis of Skeletal Metastases and Assessment of Response to Treatment.- Biochemical Markers of Bone Metabolism in Metastatic Bone Disease.- Palliative Radiotherapy of Bone Metastases.- Systemic Treatment of Bone Metastases: Review of Literature and Retrospective Analysis of 718 Breast Cancer Patients.- Bisphosphonates: Mechanism of Action and Clinical Use in Hypercalcemia of Malignancy and Tumor-Induced Bone Destruction.- Clodronate Decreases Skeletal Morbidity in Patients with Bone Metastases from Breast Cancer: A Double-Blind Randomized Controlled Trial.