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Cancer Immunotherapy Meets Oncology

In Honor of Christoph Huber

  • Book
  • © 2014

Overview

Editors:
  1. Cedrik Michael Britten

    1. Immunotherapy Development Center (IDC), TRON-Translational Oncology University Medical Center, Johannes Gutenberg University, Mainz, Germany

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  2. Sebastian Kreiter

    1. Department of Immunotherapy Development Center, TRON-Translational Oncology University Medical Center, Johannes Gutenberg-University, Mainz, Germany

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  3. Mustafa Diken

    1. Department of Immunotherapy Development Center, TRON-Translational Oncology University Medical Center, Johannes Gutenberg University, Mainz, Germany

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  4. Hans-Georg Rammensee

    1. Department of Immunology, University of Tübingen, Tübingen, Germany

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  • Provides a comprehensive update on the state of the art in cancer immunology

  • Describes the most promising therapeutic concepts, with coverage of combination therapies and personalized medicine

  • Discusses the role of biomarkers in guiding the clinical development of new treatment approaches

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Table of contents (24 chapters)

  1. Front Matter

    Pages i-ix
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  2. Immunological and Regulatory Framework for Immuno-oncology

    1. Front Matter

      Pages 1-1
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    2. From Basic Immunology to New Therapies for Cancer Patients

      • Hans-Georg Rammensee
      Pages 3-11

    3. How T Cells Single Out Tumor Cells: “And That Has Made All the Difference…”

      • Marit M. van Buuren, Pia Kvistborg, Ton N. M. Schumacher
      Pages 13-20

    4. Effects of Regulatory T Cell–Dendritic Cell Interactions on Adaptive Immune Responses

      • Tobias Bopp, Hans Christian Probst, Markus Radsak, Edgar Schmitt, Michael Stassen, Hansjörg Schild et al.
      Pages 21-27

    5. Evolution of the Regulatory Landscape for Immunomodulatory Compounds and Personalized Therapeutic Cancer Vaccines

      • Cedrik Michael Britten, Thomas Hinz, Harpreet Singh-Jasuja, Ulrich Kalinke
      Pages 29-36

    6. Immunoguiding, the Final Frontier in the Immunotherapy of Cancer

      • Sjoerd H. van der Burg, Steffen Walter, Sylvia Janetzki, Cedrik Michael Britten, Jérôme Galon, Marij J. P. Welters et al.
      Pages 37-51

    7. Developing Cancer Immunotherapies as Drugs: Setting the Stage Through Methodological Progress

      • Axel Hoos
      Pages 53-62

  3. Immunotherapies

    1. Front Matter

      Pages 63-63
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    2. Reflections on Cancer Vaccines

      • Cornelis J. M. Melief
      Pages 65-68

    3. Dendritic Cell-Based Cancer Vaccines

      • H. Westdorp, K. F. Bol, M. Coşkuntürk, G. Schreibelt, I. J. M. de Vries, C. G. Figdor
      Pages 69-87

    4. mRNA Vaccination and Personalized Cancer Therapy

      • S. Kreiter, M. Diken, U. Sahin
      Pages 89-100

    5. Antibody Therapy in Oncology

      • Martin Glennie, Özlem Türeci, Peter W. M. Johnson
      Pages 101-110

    6. Bispecific Antibodies for the Treatment of Cancer: The Challenges of Translation

      • Gundram Jung, Ludger Große-Hovest
      Pages 111-116

    7. The ABCs of T Cell Receptor Gene Therapy

      • Dolores J. Schendel, Philip D. Greenberg
      Pages 117-126

    8. The Express Drivers: Chimeric Antigen Receptor-Redirected T Cells Make It to the Clinic

      • Hinrich Abken, Winfried S. Wels, Klaus Kühlcke
      Pages 127-135

  4. Cancer Entities

    1. Front Matter

      Pages 137-137
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    2. Immunotherapy of Malignant Melanoma

      • Cedrik Michael Britten, G. Schuler, S. Grabbe
      Pages 139-154

    3. Prostate Cancer Vaccines Generated with the Disruptive RNActive® Technology Follow the Path Paved by Sipuleucel-T and Prostvac-VF

      • Karl-Josef Kallen
      Pages 155-169

    4. Recent Developments in the Active Immunotherapy of Renal Cell Cancer

      • Harpreet Singh-Jasuja
      Pages 171-178
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Keywords

About this book

This book provides a comprehensive update on the state of the art in cancer immunology, which has rapidly evolved from a field of clinical research into an established discipline of oncology. The key recent developments in immuno-oncology are all covered, from the ever-changing immunological and regulatory frameworks to the most promising therapeutic concepts. Themes include combination therapies and personalized medicine, as well as identification of biomarkers to guide the clinical development of new approaches and to pinpoint the optimal treatment for each patient. The book acknowledges the continuing dynamic nature of the field as reflected in the development of next-generation immunotherapies that are already in clinical testing.

Cancer Immunotherapy Meets Oncology is dedicated to the lifetime achievements of Christoph Huber, founder and chair of the Association for Cancer Immunotherapy (CIMT). It is also a tribute to those researchers and clinicians who are striving to develop novel diagnostics and tailored immunotherapies for the benefit of cancer patients.

Editors and Affiliations

  • Immunotherapy Development Center (IDC), TRON-Translational Oncology University Medical Center, Johannes Gutenberg University, Mainz, Germany

    Cedrik Michael Britten

  • Department of Immunotherapy Development Center, TRON-Translational Oncology University Medical Center, Johannes Gutenberg-University, Mainz, Germany

    Sebastian Kreiter

  • Department of Immunotherapy Development Center, TRON-Translational Oncology University Medical Center, Johannes Gutenberg University, Mainz, Germany

    Mustafa Diken

  • Department of Immunology, University of Tübingen, Tübingen, Germany

    Hans-Georg Rammensee

Bibliographic Information

  • Book Title: Cancer Immunotherapy Meets Oncology

  • Book Subtitle: In Honor of Christoph Huber

  • Editors: Cedrik Michael Britten, Sebastian Kreiter, Mustafa Diken, Hans-Georg Rammensee

  • DOI: https://doi.org/10.1007/978-3-319-05104-8

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing Switzerland 2014

  • Hardcover ISBN: 978-3-319-05103-1Published: 07 May 2014

  • Softcover ISBN: 978-3-319-38126-8Published: 23 August 2016

  • eBook ISBN: 978-3-319-05104-8Published: 23 April 2014

  • Edition Number: 1

  • Number of Pages: IX, 248

  • Number of Illustrations: 1 b/w illustrations, 18 illustrations in colour

  • Topics: Oncology, Cancer Research, Pharmacology/Toxicology, Immunology

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