In addition to surgery and radiotherapy, local treatment modalities for the management of brain tumours are increasingly being developed and clinically tested. This book describes for the first time basic tumour biology as well as all current procedures in progress at the most recent level of knowledge, presented by leading experts in the respective fields. Image guided resection procedures, fluorescence guided surgery, developments in interstitial radiosurgery are addressed, just as intracavitary chemotherapy and all current concepts and studies of interstitial targeted therapy. Owing to its topicality this book will remain for long the standard for this comprehensively treated subject.
Editor’s remarks: Evolving concepts for local therapies for glioma • Z. Ram, M. Hadani: Intraoperative imaging – MRI • P. C. Warnke: Stereotactic volumetric resection of gliomas • W. Stummer, H.-J. Reulen, A. Novotny, H. Stepp, J.-C. Tonn: Fluorescence-guided resections of malignant gliomas – an overview • M. Warmuth-Metz: Postoperative imaging after brain tumor resection • C. Nimsky, O. Ganslandt, B. v. Keller, R. Fahlbusch: Preliminary experience in glioma surgery with intraoperative high-field MRI • J. Jääskeläinen, T. Randell: Awake craniotomy in glioma surgery • S. C. Short: External beam and conformal radiotherapy in the management of gliomas • P. C. Warnke, K. Kopitzki, C. B. Ostertag: Interstitial stereotactic radiosurgery • P. Menei, J.-P. Benoit: Implantable drug-releasing biodegradable microspheres for local treatment of brain glioma • J. Jääskeläinen: Non-invasive transcranial High Intensity Focused Ultrasound (HIFUS) under MRI thermometry and guidance in the treatment of brain lesions • M. Westphal, K. Lamszus, D. Hilt: Intracavitary chemotherapy for glioblastoma: present status and future directions • C. Goetz, W. Rachinger, G. Poepperl, M. Decker, F.-J. Gildehaus, S. Stocker, G. Jung, K. Tatsch, J.-C. Tonn, H.-J. Reulen: Intralesional radioimmunotherapy in the treatment of malignant glioma: clinical and experimental findings • M. Ravic: Intracavitary treatment of malignant gliomas: radioimmunotherapy targeting fibronectin • A. Merlo, J. Mueller-Brand, H. R. Maecke: Comparing monoclonal antibodies and small peptidic hormones for local targeting of malignant gliomas • F. W. Weber, F. Floeth, A. Asher, R. Bucholz, M. Berger, M. Prados, S. Chang, J. Bruce, W. Hall, N. G. Rainov, M. Westphal, R. E. Warnick, R. W. Rand, F. Rommel, H. Pan, V. N. Hingorani, R. K. Puri: Local convection enhanced delivery of IL4-Pseudomonas exotoxin (NBI-3001) for treatment of patients with recurrent malignant glioma •S. Kunwar: Convection enhanced delivery of IL13-PE38QQR for treatment of recurrent malignant glioma: presentation of interim findings from ongoing phase 1 studies • N. G. Rainov, H. Ren: Oncolytic viruses for treatment of malignant brain tumours • W. Hamel, M. Westphal: Gene therapy of gliomas • R. Bjerkvig, T.-A. Read, P. Vajkoczy, P. Aebischer, W. Pralong, S. Platt, J. E. Melvik, A. Hagen, M. Dornish: Cell therapy using encapsulated cells producing endostatin • M. Kirsch, O. Heese, M. Westphal, G. Schackert: Stem cells in neuro-oncology – development, regeneration and treatment • A. Giese: Glioma invasion – Pattern of dissemination by mechanisms of invasion and surgical intervention, pattern of gene expression and its regulatory control by tumorsuppressor p53 and proto-oncogene ETS-1 • J. C. Tonn, R. Goldbrunner: Mechanisms of glioma cell invasion • K. Lamszus, P. Kunkel, M. Westphal: Invasion as limitation to anti-angiogenic glioma therapy Author Index • Index of Keywords