Molecular Pathology of Gynecologic Cancer focuses on putting successful molecular strategies into practice for the treatment of gynecologic cancer. The volume begins with an explication of the editors’ hypothesis that cancer is mainly a disease of the cell cycle, based on the deregulation of the physiological process of cell reproduction.
The following eleven chapters focus on specific issues in gynecologic cancers, including: a proposed model of ovarian serous carcinogenesis, molecular markers for ovarian epithelial cancer, an overview of the pathology of endometrial cancer, molecular genetic aspects of endometrial carcinoma and cervical cancer, a natural history of Human Papilloma Virus (HPV) as it relates to cervical cancer, and hereditary issues in gynecologic cancers. The concluding chapter proposes and outlines a holistic approach to the treatment of female cancer patients.
This new volume in Humana’s Current Clinical Oncology™ series will be necessary reading for clinicians and experimental researchers alike.
MOLECULAR PATHOLOGY OF GYNECOLOGIC CANCER
EDITORS : ANTONIO GIORDANO , M.D., Ph.D.
ALESSANDRO BOVICELLI , M.D., Ph.D.
ROBERT J. KURMAN, M.D., Ph.D.
Alessandro Bovicelli and Giovan Giacomo Giordano, Honorary President of the Italian Tumor Society (SIT)
PART I : INTRODUCTION
***Chapter 1 : The Cell Cycle and the Molecular Biology of Cancer
Giuseppina D'Andrilli, Alessandro Bovicelli and Antonio Giordano
Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, BioLife Science Building, Suite 333, 1900 N 12th Street. Philadelphia, PA, 19122.
This chapter evaluates the molecules that conduct progression through the cell cycle and describes their activities that are linked together to control the process of cell reproduction. In light of these concepts, we believe that cancer is mainly a disease of the cell cycle based on the deregulation of this physiological process. This hypothesis is further elaborated upon and illustrated in the subsequent chapters .
PART II : OVARIAN CANCER :
***Chapter 2 : Ovarian Serous Carcinogenesis-A Proposed Model
Ie-Ming Shih and Robert. J Kurman
Department of Pathology, The Johns Hopkins University School of Medicine, 401 North Broadway, Baltimore, Maryland, 21231-2410, USA.
This chapter discusses the most innovative pathological issues that define ovarian neoplasia. The emphasis is placed on different ovarian pathways of carcinogenesis and progression to advanced disease. Particular focus is directed to borderline disease and its classification.
***Chapter 3 : Molecular Markers in Epithelial Ovarian Cancer.
Laboratory of Cellular and Molecular Biology, Gerontology Research Center, NationalInstitute on Aging, Building 31, Room 5C27, 31 Center Drive, MSC 2292, Bethesda, MD 20892, email@example.com
This chapter summarizes the studies which have correlated cancer screening, diagnosis and prognosis with structure and expression profiles of molecular markers. New insights made possible by the utilization of new technologies are discussed. The emphasis is placed on cell cycle regulatory genes . The diversity of cancer types and the value of examining multi-gene profiles is discussed in this chapter.
PART III : ENDOMETRIAL CANCER :
***Chapter 4 : Introduction to Endometrial Cancer.
Department of Pathology, Milton S. Hershey Medical Center of Pennsylvania State University, Hershey, Pennsylvania 17033, USA
This chapter discusses the most innovative pathological issues that define endometrial neoplasia . Special focus is placed on pre-neoplastic lesions. The criteria established for distinguishing lesions on the basis of architectural and cytological abnormalities are examined. Differences between simple or complex hyperplasia with or without atypia are also stressed. Histological types of advanced disease and implications for a different course of the disease are examined.
***Chapter 5 : Endometrial Carcinogenesis : An Integrated, Molecular, Histologic and Functional Model of a Dualistic Disease.
Pathology Institute, Brigham and Women's Hospital, 02115 Boston, Massachusetts.
Among the hormone-related carcinomas, the best understood etiologically is endometrial cancer. The demographic characteristics of the disease as well as the non-demographic risk factors are mainly due to a cumulative exposure of the endometrium to that fraction of estrogen that is unopposed by the influence of progesterone. On the other hand, recent data in the literature defined two distinct pathways of endometrial carcinogenesis an