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Death Receptors in Cancer Therapy

  • Book
  • © 2005

Overview

Editors:
  1. Wafik S. El-Deiry

    1. Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia
      Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia
      Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Mammalian Cell Death Pathways

    • E. Robert McDonald III, Wafik S. El-Deiry
    Pages 1-41

  3. Resistance to Apoptosis in Cancer Therapy

    • David J. McConkey
    Pages 43-64

  4. Structures of TNF Receptors and Their Interactions With Ligands

    • Sarah G. Hymowitz, Abraham M. de Vos
    Pages 65-81

  5. Death Receptor Signaling in Embryonic Ectodermal Development

    • Preet M. Chaudhary
    Pages 83-92

  6. Adaptor Proteins in Death Receptor Signaling

    • Nien-Jung Chen, Wen-Chen Yeh
    Pages 93-109

  7. Caspase Activation by the Extrinsic Pathway

    • Xiaolu Yang
    Pages 111-131

  8. Death Signaling and Therapeutic Applications of TRAIL

    • Mi-Hyang Kim, Dai-Wu Seol
    Pages 133-148

  9. Death Receptor Mutations

    • Sug Hyung Lee, Nam Jin Yoo, Jung Young Lee
    Pages 149-162

  10. Regulation of Death Receptors

    • Udo Kontny, Heinrich Kovar
    Pages 163-173

  11. Regulation of Trail Receptor Expression in Human Melanoma

    • Peter Hersey, Si Yi Zhang, Xu Dong Zhang
    Pages 175-187

  12. Regulation of Death Receptors by Synthetic Retinoids

    • Shi-Yong Sun
    Pages 189-200

  13. Role of p53 in Regulation of Death Receptors

    • Rishu Takimoto
    Pages 201-206

  14. Proapoptotic Gene Silencing Via Methylation in Human Tumors

    • Tanya Tekautz, Tal Teitz, Jill M. Lahti, Vincent J. Kidd
    Pages 207-229

  15. Regulation of Death Receptor-Induced Apoptosis by NF-κB and Interferon Signaling Pathways

    • Rajani Ravi, Atul Bedi
    Pages 231-261

  16. TRAIL in Cancer Therapy

    • Mahaveer Swaroop Bhojani, Brian D. Ross, Alnawaz Rehemtulla
    Pages 263-279

  17. Expression and Regulation of Death Receptors in Multiple Myeloma and Prostate Carcinoma

    • Subrata Ray, John G. Hissong, Marcela Oancea, Alex Almasan
    Pages 281-296

  18. Regulation of TRAIL-Induced Apoptosis by Transcriptional Factors

    • Rüdiger Göke, Youhai H. Chen
    Pages 297-303

  19. Sensitizing Tumor Cells by Targeting Death Receptor Signaling Inhibitors

    • Christina Voelkel-Johnson
    Pages 305-321

  20. Ceramide, Ceramidase, and FasL Gene Therapy in Prostate Cancer

    • James S. Norris, David H. Holman, Marc L. Hyer, Alicja Bielawska, Ahmed El-Zawahry, Charles Chalfant et al.
    Pages 323-338
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Keywords

About this book

An in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particular interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands.

Reviews

From the reviews:

"The book is resourceful for both basic scientists and clinicians, who are interested in developing targeted therapies for cancer. … the book is a valuable tool for researchers as well as to those of us involved in teaching apoptosis to undergraduate and graduate students." (Harikrishna Nakshatri, Leukemia Research, 2005)

Editors and Affiliations

  • Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia

    Wafik S. El-Deiry

  • Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia

    Wafik S. El-Deiry

  • Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia

    Wafik S. El-Deiry

Bibliographic Information

  • Book Title: Death Receptors in Cancer Therapy

  • Editors: Wafik S. El-Deiry

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1385/159259851X

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Humana Press 2005

  • Hardcover ISBN: 978-1-58829-172-1Published: 03 December 2004

  • Softcover ISBN: 978-1-61737-401-2Published: 19 November 2010

  • eBook ISBN: 978-1-59259-851-9Published: 15 November 2007

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: XII, 374

  • Topics: Oncology

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