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DNA Tumor Viruses

Oncogenic Mechanisms

  • Book
  • © 1995

Overview

Editors:
  1. Giuseppe Barbanti-Brodano

    1. Institute of Microbiology, School of Medicine, University of Ferrara, Ferrara, Italy

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  2. Mauro Bendinelli

    1. University of Pisa, Pisa, Italy

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    You can also search for this editor in PubMed   Google Scholar

  3. Herman Friedman

    1. University of South Florida, Tampa, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Infectious Agents and Pathogenesis (IAPA)

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-xxiv
    Download chapter PDF

  2. The Hamster Polyomavirus

    • Siegfried Scherneck, Jean Feunteun
    Pages 1-14

  3. Simian Virus 40 Large T Antigen Induces Chromosome Damage that Precedes and Coincides with Complete Neoplastic Transformation

    • F. Andrew Ray
    Pages 15-26

  4. Transformation by Polyomaviruses

    • Daniel T. Simmons
    Pages 27-50

  5. Association of BK and JC Human Polyomaviruses and SV40 with Human Tumors

    • Paolo Monini, Laura de Lellis, Giuseppe Barbanti-Brodano
    Pages 51-73

  6. Association of Simian Virus 40 with Rodent and Human Mesotheliomas

    • Michele Carbone, Paola Rizzo, Harvey I. Pass
    Pages 75-90

  7. Immortalization of Keratinocytes by Human Papillomaviruses

    • Craig D. Woodworth, Joseph A. DiPaolo
    Pages 91-109

  8. Cooperation between Bovine Papillomaviruses and Dietary Carcinogens in Cancers of Cattle

    • Maria E. Jackson, M. Saveria Campo
    Pages 111-122

  9. Papillomaviruses as Promoting Agents in Human Epithelial Tumors

    • Christa Cerni, Christian Seelos
    Pages 123-155

  10. Vaccines against Human Papillomaviruses and Associated Tumors

    • Lionel Crawford
    Pages 157-169

  11. The Complex Role of Hepatitis B Virus in Human Hepatocarcinogenesis

    • Marie Annick Buendia, Pascal Pineau
    Pages 171-193

  12. Transformation and Tumorigenesis Mediated by the Adenovirus E1A and E1B Oncogenes

    • Robert P. Ricciardi
    Pages 195-225

  13. Current Developments in the Molecular Biology of Marek’s Disease Virus

    • Meihan Nonoyama, Akiko Tanaka
    Pages 227-238

  14. Oncogenic Transformation of T Cells by Herpesvirus saimiri

    • Peter G. Medveczky
    Pages 239-252

  15. Transformation and Mutagenic Effects Induced by Herpes Simplex Virus Types 1 and 2

    • Laure Aurelian
    Pages 253-280

  16. Herpes Simplex Virus as a Cooperating Agent in Human Genital Carcinogenesis

    • Dario Di Luca, E. Caselli, E. Cassai
    Pages 281-293

  17. Human Cytomegalovirus

    • K. Radsak, H. Kern, B. Reis, M. Reschke, T. Mockenhaupt, M. Eickmann
    Pages 295-312

  18. Association of Human Herpesvirus 6 with Human Tumors

    • Dario Di Luca, Riccardo Dolcetti
    Pages 313-326

  19. Molecular Mechanisms of Transformation by Epstein-Barr Virus

    • Nancy S. Sung, Joseph S. Pagano
    Pages 327-346

  20. Epstein-Barr Virus

    • Layla Karimi, Dorothy H. Crawford
    Pages 347-373
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Keywords

About this book

DNA tumor viruses have long been useful experimental models of carcinogenesis and have elucidated several important mechanisms of cell transformation. Re­ search in recent years has shown that human tumors have a multifactorial nature and that some DNA tumor viruses may playa key role in their etiology. The aim of this book is to assess our knowledge of DNA tumor viruses by reviewing animal models, mechanisms of transformation, association with human tumors, and possi­ bilities of prevention and control by vaccination. Animal models of tumor virology have contributed significantly to our under­ standing of the epidemiology and pathogenesis of virus-induced tumors. Bovine papillomaviruses induce papillomas in the intestine of cattle. The papillomas undergo a transition to carcinomas in cows feeding on bracken fern, which pro­ duces a toxin with radiomimetic and immunosuppressive functions. This example of cooperation between a virus and chemical carcinogens parallels the cooperative role of human papillomaviruses (HPVs) and herpes simplex virus type 2 (HSV-2) with environmental carcinogens in the pathogenesis of cervical cancer. Likewise, hepatocarcinomas appearing in woodchucks chronically infected by woodchuck hepatitis virus (WIN) provide strong support for the relationship between hepatitis B virus (HBV) infection and human hepatocellular carcinoma. Also, the fact that WIN DNA integrates closely to cellular oncogenes suggests a possible molecular mechanism for the tumorigenesis induced by HBV.

Editors and Affiliations

  • Institute of Microbiology, School of Medicine, University of Ferrara, Ferrara, Italy

    Giuseppe Barbanti-Brodano

  • University of Pisa, Pisa, Italy

    Mauro Bendinelli

  • University of South Florida, Tampa, USA

    Herman Friedman

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