Etiology of Cancer in Man

1. Front Matter

   Pages I-XI

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2. Neoplastic Diseases — Multistep Maladies

   • H. E. Kaiser

   Pages 1-2

3. Relationships Between Malignant and Non-Malignant Disease of Western Culture

   • Denis P. Burkitt

   Pages 3-6

4. Genetic Diseases, Hamartomas, and Familial Occurrence of Neoplasms

   • David T. Purtilo, James Linder, George Manolov, Yanka Manolova

   Pages 7-25

5. Genetic Evaluation of Ontologically Related Neural Crest Tumors

   • Catherine McKeon, Carol J. Thiele, Timothy J. Triche, Mark A. Israel

   Pages 26-37

6. Multiple Primary Neoplasms: Comparison Between Japan and the U.S.A.

   • Mitsuhiro Kamakura, Haruo Kondo, Shaw Watanabe

   Pages 38-43

7. Selected Aspects of Primary Liver Carcinoma in Japan

   • Kunio Okuda

   Pages 44-51

8. Effects of Localized and Disseminated Cancers on Metabolism and Nutrition in Man

   • David Heber, Lauri O. Byerley

   Pages 52-57

9. The Natural Untreated Course of Breast Cancer

   • A. Gregl, C. J. Harrington, O. S. Cigtay

   Pages 58-69

10. Hormone Dependent Breast Cancer

    • Charles F. LeMaistre, William L. McGuire

    Pages 70-79

11. Prolactin and Estrogen in Mammary Tumorigenesis

    • Hiroshi Nagasawa

    Pages 80-86

12. Assessment of the Endocrine Risk of Developing Breast Cancer

    • R. C. Hermida, F. Halberg

    Pages 87-101

13. Appearance of Neoplasms during Pregnancy

    • C. E. Mesonero

    Pages 102-114

14. Urbanization Parameters as Moderators of the Background Radiation-Leukemia Connection

    • Hans W. Wendt, Kristine A. Birdsey

    Pages 115-121

15. Radiation Therapy-Induced Neoplasms

    • H. E. Kaiser

    Pages 122-131

16. Chemotherapy-Induced Neoplasms, Side Effects, and Drug Carcinogenicity

    • H. E. Kaiser

    Pages 132-135

17. Malignant Neoplasms in Organ Transplant Recipients

    • Annabel G. Liebelt

    Pages 136-167

18. Neoplastic Progression Induced by Asbestos (Mesothelioma)

    • Marcella Klima

    Pages 168-179

19. The Concept of the Immune Reaction in Oncogenesis: A Host Tumor Interaction

    • H. C. Outzen, R. T. Prehn

    Pages 180-183

20. Aids Epidemic and Neoplasms

    • R. Ben Dawson

    Pages 184-189

This volume reviews our current knowledge concerning can­ Several chapters discuss the contributions of genetic asp­ cer growth and progression as it relates to the etiology of ects, metabolism, endocrine-related aspects and nutrition to human cancer. As emphasized in Volumes I-V of this series, cancer progression. Moreover, our current knowledge con­ neoplastic diseases are multistep maladies. There are many cerning urbanization factors, radiation, therapy-induced causes for the appearance of neoplastic diseases. Earlier neoplasms, environmentally induced neoplasms (e. g. , chapters in the series have reviewed molecular and cellular mesotheliomas induced by asbestos) and malignant neo­ aspects of tumor initiation, promotion and progression to plasms in organ transplant recipients are summarized. the invasive and metastatic phenotype. Contributions to the The impact of AIDS on neoplasm development is re­ initiation and progression of neoplastic diseases are made by viewed from an epidemiologic perspective that explores mul­ natural features of the environment and by its contaminants tiple facets of immunity, infectious disease, sexual behavior and by nutritional factors. Neoplastic diseases show a dis­ and blood transfusion. Other chapters investigate the in­ tinct relationship to a variety of environmental stimuli and fluence of the host immune response in oncogenesis and the to diseases of a non-neoplastic nature. For example, familial relationship between atherosclerotic plaques and tumors.

• AIDS
• cancer
• carcinoma
• hormones
• leukemia
• liver
• mesothelioma
• pregnancy
• tumor
• tumorigenesis

• National Institutes of Child Health & Human Development, National Institutes of Health, Bethesda, USA

  Arthur S. Levine

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