Emerging Concepts in Neuro-Oncology

1. Front Matter

   Pages i-x

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2. Scientific Foundations

   1. Front Matter

      Pages 1-1

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   2. Classification of Gliomas

      • Pieter Wesseling

      Pages 3-20

   3. Epigenetics and Brain Cancer

      • Davide Sciuscio, Monika E. Hegi

      Pages 21-40

   4. Astrocyte Differentiation from Oligodendrocyte Precursors

      • Akiko Nishiyama

      Pages 41-60

   5. Stem Cells and Brain Cancer

      • Sara G. M. Piccirillo

      Pages 61-71

3. Models of Brain Cancer

   1. Front Matter

      Pages 73-73

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   2. In Vitro Models of Brain Cancer

      • David J. Ryan, Colin Watts

      Pages 75-86

   3. Mouse Models of Glioma Pathogenesis: History and State of the Art

      • Sebastian Brandner

      Pages 87-107

   4. The Application of Novel Ionizing Radiation Species for Glioblastoma

      • Raj Jena

      Pages 109-117

   5. Advances in Imaging Brain Cancer

      • Stephen J. Price, Adam D. Waldman

      Pages 119-140

4. Emerging Concepts in Clinical Practice

   1. Front Matter

      Pages 141-141

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   2. Surgical Management of Glial Cancers

      • Walter Stummer

      Pages 143-159

   3. Radiation Oncology in Brain Cancer

      • Susan C. Short

      Pages 161-170

   4. Managing the Elderly Patient

      • Kathryn Graham, Anthony J. Chalmers

      Pages 171-196

   5. Brain Tumor Presentation in Children and Young People

      • David A. Walker, Sophie H. Wilne

      Pages 197-205

   6. How Can We Improve Clinical Trial Recruitment in Neuro-Oncology?

      • Sarah J. Jefferies

      Pages 207-215

5. Back Matter

   Pages 217-220

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Having been a fairly dormant specialty for many decades, in recent years there has been a remarkable increase in activity in Neuro-oncology from basic science through to the clinics. Reflecting this there have been considerable advancements in the understanding of the biology of CNS malignancies which have infirmed the development of many novel and successful therapies. This work aims to bring together the scattered literature on the new concepts in neuro-oncology for the benefit of those in the field. The book moves from concepts in the scientific basis of neuro-oncology, through to modelling techniques and finishing on the translation into clinical practice.

• CNS Malignancies
• Clinical Oncology
• Neuro-Oncology
• Neurosciences

From the book reviews:

“This is an up to date reference on the surgical, chemotherapy, and radiosurgery of gliomas, both low and high grade neoplasms. … I highly recommend this book for neurosurgeons, oncologists, radiation researchers, fellows and students.” (Joseph J. Grenier, Amazon.com, October, 2014)

“In this book, the authors aim to comprehensibly describe new findings, as well as established facts, and to discuss their influence on current and possible future therapies. … this is a well written book on current advances in the field of neuro-oncology. It is worth reading for basic researchers working in the field of neuro-oncology, as well as neuro-oncologists and neurosurgeons.” (Anne-Katrin Hickmann, Innovative Neurosurgery, Vol. 1 (1), 2013)

• , Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom

  Colin Watts

Colin Watts is a Clinician Scientist and Honorary Consultant Neurosurgeon at the Department of Clinical Neurosciences, Cambridge Centre for Brain Repair and Neurosurgery Unit, Cambridge University.

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