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Concepts, Mechanisms, and New Targets for Chemotherapy

  • Book
  • © 1995

Overview

Editors:
  1. F. M. Muggia

    1. University of Southern California Cancer Center, USA

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Part of the book series: Cancer Treatment and Research (CTAR, volume 78)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-x
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  2. Concepts and Mechanisms

    1. Front Matter

      Pages 1-1
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    2. Potential for protein kinase C inhibitors in cancer therapy

      • Philip A. Philip, Adrian L. Harris
      Pages 3-27

    3. Recent clinical advances with camptothecin analogues

      • William J. Slichenmyer, Ross C. Donehower
      Pages 29-43

    4. The reversal of multidrug resistance

      • George A. Fisher, Bert L. Lum, Branimir I. Sikic
      Pages 45-70

    5. Fluoropyrimidine catabolism

      • Robert B. Diasio, Zhihong Lu, Ruiwen Zhang, Harout S. Shahinian
      Pages 71-93

    6. Use of hydroxyurea to alter drug resistance of human tumor cells

      • Carla Van Den Berg, Daniel D. Von Hoff
      Pages 95-114

    7. Aspects of one-carbon folate cycling related to fluoropyrimidine and antifolate therapy

      • Colin Paul Spears, Göran Carlsson, Franco M. Muggia, George Jaresko, Bengt G. Gustavsson
      Pages 115-134

  3. Disease Targets

    1. Front Matter

      Pages 135-135
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    2. Systemic therapy of skin carcinoma

      • Raymond A. Kempf
      Pages 137-162

    3. Estramustine revisited

      • Willi Kreis
      Pages 163-184

    4. Taxoid compounds in breast cancer: current status and future prospects

      • Martine J. Piccart
      Pages 185-207

    5. High-dose chemotherapy with peripheral blood progenitor autografting

      • John P. Crown, David Fennelly
      Pages 209-226

  4. Back Matter

    Pages 227-237
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Keywords

About this book

Concepts, Mechanisms, and New Targets for Chemotherapy describes new interconnections between rationally designed and empirically discovered compounds. One route that has not been travelled previously is that of protein kinase C inhibition. This pathway may be exploited to give potent inhibitors, such as the bryostatins, now in clinical trial. A summary is given of the current status of topoisomerase, focusing on recent clinical advances with camptothecin analogs based on connecting empiricism with concepts of drug selectivity.
Modification of existing therapies based on the pursuit of leads arising from mechanistic studies is also being applied clinically on a wide scale. Greater understanding should follow from the studies of reversal of the multidrug resistant phenotype, on the use of hydroxyurea to reverse resistance mediated by extrachromosomal DNA, and on various aspects of the fluoropyrimidine pathways.
Successful applications of chemotherapy to the treatment of specific diseases include the growing applications of systemic therapy using various skin malignancies. In prostate cancer, estramustine phosphate will likely play an expanding role. Taxanes are restructuring treatment regimens in breast cancer, and high-dose strategies are described with peripheral blood progenitor autografting in the treatment of ovarian and breast cancers.

Editors and Affiliations

  • University of Southern California Cancer Center, USA

    F. M. Muggia

Bibliographic Information

  • Book Title: Concepts, Mechanisms, and New Targets for Chemotherapy

  • Editors: F. M. Muggia

  • Series Title: Cancer Treatment and Research

  • DOI: https://doi.org/10.1007/978-1-4615-2007-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1995

  • Hardcover ISBN: 978-0-7923-3525-2Published: 31 December 1995

  • Softcover ISBN: 978-1-4613-5829-9Published: 22 December 2012

  • eBook ISBN: 978-1-4615-2007-8Published: 06 December 2012

  • Series ISSN: 0927-3042

  • Series E-ISSN: 2509-8497

  • Edition Number: 1

  • Number of Pages: X, 237

  • Topics: Oncology, Cancer Research, Medicine/Public Health, general

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