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` ... I would recommend the book to biostatisticians who want to stay up-to-date on recent developments in the design and analysis of clinical trials.' Annals of Oncology, 7 (1996) ` ... I can certainly recommend it as a very useful addition to a multidisciplinary library. Many of the topics coverd are yet to reach standard textbooks; their accumulation under one title is a valuable contributions.' Clinical Oncology, 9:4 (1997)