With the publication of these proceedings from the Second Drug Discovery and Development Symposium, this forum has become the main mechanism for bringing together the principal groups involved in both discovering and developing new approaches to the treatment of cancer. This Second Symposium emphasized the types of materials being discovered and their therapeutic activity. This is especially evident in the natural product discovery programs, where unique and active structures are being identified.
The major contributors to the meeting were the investigators participating in the National Cooperative (Natural Products) Drug Discovery Groups [NC(NP)DDG]. These groups reflect an association among researchers at universities or cancer centers, pharmaceutical companies and the National Cancer Institute. Their sources of materials are varied, reflecting chemical inventories of pharmaceutical companies, organic synthetic compounds from the laboratory, cytotoxics as well as biologics and their hybrids, and natural products obtained from plants, marine organisms and microorganisms. The models employed in the discovery systems vary from broadly cellular based to specific enzymes to defined cellular functions. Each of them is believed important to the malignant state and will allow for the discovery of compounds which will have efficacy in cancer therapy.
The goal of the participants is both to discover new anticancer agents and to develop them as efficiently as possible into clinically useful additions to treatment. Of importance is the fact that there are a number of promising leads which will soon be moving into the clinic thereby testing the effectiveness of this NC (NP) DDG approach.
1. Discovery of Natural Products from Microalgae and Marine Organisms; F. Valeriote, R.E. Moore, G.M.L. Patterson, V.J. Paul, P.J. Scheuer, T. Corbett. 2. Discovery of Naturally Occurring Antitumor Agents; Ching-Jer Chang, C.L. Ashendel, R.L. Geahlen, J.L. McLaughlin. 3. Marine Invertebrates and Microbes as Sources of Potential Antitumor Compounds; A.L. Staley, J. Clardy. 4. Novel Strategies for the Discovery of Plant-Derived Anticancer Agents; G.A. Cordell, N.R. Farnsworth, C.W.W. Beecher, D.Doel Soejarto, A.D. Kinghorn, J.M. Pezzuto, M.E. Wall, M.C. Wani, R.R. Cobb, M.J. o'Neill, R.M. Tait, T.J.R. Harris. 5. A Strategy for Identifying Novel Inhibitors of DNA Topoisomerase I; S.M. Hecht, D.E. Berry, L.J. Mackenzie, E.A. Shultis, J.A. Chan. 6. Altromycins: a New Family of Antitumor Antibiotics-Discovery and Biological Evaluation; J.B. McAlpine, J.P. Karwowski, M. Jackson, G.M. Brill, S. Kadam, L. Shen, J.J. Clement, J. Alder, N.S. Burres. 7. Suppression of Human Melanoma Metastasis in SCID Mice with Antibodies to the EGF-Receptor; B.M. Mueller, R.A. Reisfeld. 8. Growth Factor and Oncogene Signalling as a Target for Anticancer Drug Development; G. Powis. 9. Nucleoside and Nucleotide Modulation of Oncogenic Expression: a New Approach to Cancer Chemotherapy; R.K. Robins, R.A. Finch, T.L. Avery. 10. Interferons in Cancer Therapy: from Clinical Trials to New Potentials in Anticancer Drug Discovery and Development; G.G. Steinmann, G.R. Adolf, G. Leitz. 11. Selection and Manipulation of Immunoglobulins for Radionuclide Delivery; Z. Steplewski, P. Curtis, J. Hainfield, R. Mease, S. Srivastava. 12. Microorganisms: Strategic Sources of Novel Anti-Tumor Agents; J.B. Tunac. 13. The Therapeutic Potential of Novel Pure Antiestrogens; A.E. Wakeling. 14. Preclinical Pharmacology and Phase I Clinical Trials of Taxotere (RP 56976, NSC 628503); M.-C. Bissery, H. Burris, R. Pazdur. 15. Bropriimine, a Small-Molecule Biological Response Modifier and an Effective Antitumor Agent; Li H. Li. 16. Determinants of Etoposide Cytotoxicity in vitro; R.B. Lock. 17. Screening for Anticancer Leads from Marine Organisms in a Mechanism-Based Drug Discovery Program; P. Crews, D.L. Slate, W.H> Gerwick, F.J. Schmitz, R. Schatzman, B. Strulovici, P. Cannon, L.M. Hunter.