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Genetics of Colorectal Cancer

  • Book
  • © 2009

Overview

Editors:
  1. John D. Potter

    1. Member and Senior Advisor Fred Hutchinson Cancer Research Center, Seattle, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Noralane M. Lindor

    1. Department of Medical Genetics, Mayo Clinic College of Medicine, Rochester, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Will explore the latest findings in the area of genetic susceptibility to gastrointestinal cancers, focusing on molecular epidemiology, DNA repair, and gene-environment interactions to identify factors that affect the incidence of GI cancers
  • Includes supplementary material: sn.pub/extras

Part of the book series: Cancer Genetics (CANGENETICS)

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Epidemiology and Models of Colorectal Cancer

    1. Colorectal Cancer: Epidemiology

      • John D. Potter, David Hunter
      Pages 5-25

    2. Mouse Models of Intestinal Cancer

      • Erin M. Perchiniak, Joanna Groden
      Pages 27-49

  3. Pathways to Colorectal Cancer

    1. The Chromosomal-Instability Pathway and APC Gene Mutation in Colorectal Cancer

      • Robert Gryfe
      Pages 53-72

    2. DNA Methylation in Colorectal Cancer: Multiple Facets of Tumorigenesis

      • Joanne P. Young, Peter W. Laird
      Pages 73-95

    3. Pathways and Pathology

      • Jeremy R. Jass
      Pages 97-121

  4. Germline Susceptibility – Mendelian and Other Syndromes

    1. Familial Adenomatous Polyposis

      • Julian A. Sanchez, Graham Casey, James M. Church
      Pages 125-139

    2. DNA Mismatch Repair and Lynch Syndrome

      • Brittany C. Thomas, Matthew J. Ferber, Noralane M. Lindor
      Pages 141-169

    3. Additional Syndromes with Hereditary Predisposition to Colorectal Cancer

      • Spring Holter, Steven Gallinger
      Pages 173-181

    4. Additional Syndromes with Hereditary Predisposition to Colorectal Cancer

      1. Familial Colorectal Cancer Type X
        • Noralane M. Lindor
        Pages 183-186
      2. Families with Serrated Neoplasia of the Colon
        • Joanne P. Young
        Pages 187-191
      3. Peutz–Jeghers Syndrome
        • Douglas L. Riegert-Johnson, Lisa A. Boardman
        Pages 193-198
      4. Juvenile Polyposis
        • Kara A. Mensink, Jeremy R. Jass, Noralane M. Lindor
        Pages 199-205
      5. <i>BLM</i> Mutation and Colorectal Cancer Susceptibility
        • Beatriz Russell, Joanna Groden
        Pages 207-212
      6. The Role of <i>p53</i> in Colorectal Cancer
        • Serena Masciari, Sapna Syngal
        Pages 213-217
      7. Chromosomes 8q24 and 9p24: Associations with Colorectal Cancer
        • John D. Potter
        Pages 219-220

  5. Germline Susceptibility – Gene-Environment Interactions

    1. Genetic Variability in Folate-Mediated One-Carbon Metabolism and Risk of Colorectal Neoplasia

      • Amy Y. Liu, Cornelia M. Ulrich
      Pages 223-242

    2. Genetic Variability in NSAID Targets and NSAID-Metabolizing Enzymes and Colorectal Neoplasia

      • Elizabeth M. Poole, James T. Cross, John D. Potter, Cornelia M. Ulrich
      Pages 243-260

    3. The Role of Chemical Carcinogens and Their Biotransformation in Colorectal Cancer

      • Loïc Le Marchand
      Pages 261-276

    4. Calcium and Vitamin D

      • Roberd M. Bostick, Michael Goodman, Eduard Sidelnikov
      Pages 277-298
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Keywords

About this book

Genetic susceptibility refers to how variations in a person’s genes increase or decrease his or her susceptibility to environmental factors, such as chemicals, radiation and lifestyle (diet and smoking). This volume will explore the latest findings in the area of genetic susceptibility to gastrointestinal cancers, focusing on molecular epidemiology, DNA repair, and gene-environment interactions to identify factors that affect the incidence of GI cancers. Topics will include germline susceptibility, including Mendelian patterns of inheritance and gene-environment interactions that lead to cancer etiology.

Editors and Affiliations

  • Member and Senior Advisor Fred Hutchinson Cancer Research Center, Seattle, USA

    John D. Potter

  • Department of Medical Genetics, Mayo Clinic College of Medicine, Rochester, USA

    Noralane M. Lindor

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