The Biology of Tumors

1. Front Matter

   Pages i-xi

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2. The Role for ink4a in Melanoma Pathogenesis

   • Jason Pomerantz, Nicole Schreiber-Agus, Nanette Liegeois, Alice Tam, Kenneth P. Olive, Ronald A. DePinho et al.

   Pages 1-14

3. Identification and Characterization of Collaborating Oncogenes in Compound Mutant Mice

   • Anton Berns, John Allen, Harald Mikkers, Blanca Scheijen, Jos Jonkers

   Pages 15-30

4. The Transcription Factor B-Myb is Phosphorylated and Activated by Cyclin A/Cdk2

   • Olaf Bartsch, Ulrike Ziebold, Richard Marais, Karl-Heinz Klempnauer, Stefano Ferrari

   Pages 31-41

5. Distinct Dynamics and Regulatory Signal Transduction of Cell Migration

   • F. Entschladen, K. Maaser, M. Gunzer, P. Friedl, B. Niggemann, K. S. Zänker

   Pages 43-49

6. Genomic Instability in Sporadic Colorectal Cancer

   • Garth R. Anderson, Daniel L. Stoler, Morton S. Kahlenberg, Nicholas J. Petrelli

   Pages 51-56

7. APC and the Early Events of Colon Cancer

   • Raymond L. White

   Pages 57-64

8. Genome Scanning and Gene Discovery in Breast and Ovarian Cancer

   • Joe W. Gray, Colin Collins, Daniel Pinkel, Laleh Shayesteh, Yiling Lu, Gordon Mills

   Pages 65-72

9. Failure of Tumor Immunity Resulting from Inaccessibility of Activated Lymphocytes to Solid Tumors

   • Ruth Ganss, Douglas Hanahan

   Pages 73-84

10. Deciphering Molecular Circuitry Using High-Density DNA Arrays

    • David H. Mack, Edward Y. Tom, Mamatha Mahadev, Helin Dong, Michael Mittmann, Suzanne Dee et al.

    Pages 85-108

11. Use of cDNA Microarrays to Assess DNA Gene Expression Patterns in Cancer

    • Paul S. Meltzer, Michael Bittner, Mervi Heiskanen, Tiffany Hoffman, Yidong Chen, Jeffrey M. Trent

    Pages 109-116

12. EH, a Novel Protein

    • Margherita Doria, Anna Elisabetta Salcini, Stefano Confalonieri, Elisa Santolini, Gioacchin Iannolo, Pier Giuseppe Pelicci et al.

    Pages 117-125

13. Deregulation of Cyclin D1 in Cancer

    • Rob Michalides

    Pages 127-143

14. Dysregulation of Programmed Cell Death in Cancer toward a Molecular Understanding of Bcl-2

    • John C. Reed

    Pages 145-171

15. Characterization of Antigens Recognized by T Cells on Human Tumors

    • Pierre G. Coulie, Benoît J. Van den Eynde, Pierre van der Bruggen, Aline Van Pel, Etienne De Plaen, Thierry Boon

    Pages 173-183

16. Identification of Human Tumor Antigens Using the B-Cell Repertoire

    • Michael Pfreundschuh, Özlem Türeci, Ugur Sahin

    Pages 185-198

17. T Cell Tolerance versus Tumor Immunity or Autoimmunity

    • Pamela S. Ohashi, Daniel E. Speiser

    Pages 199-212

18. Manipulation of T Cell Activation in the Anti-Tumor Immune Response

    • Arthur A. Hurwitz, Dana R. Leach, Andrea van Elsas, Sarah E. Townsend, James P. Allison

    Pages 213-222

19. General Discussion

    • Enrico Mihich, Carlo Croce

    Pages 223-230

20. Cytokines and Tumor Immunogenicity

    • Federica Cavallo, Katia Boggio, Mirella Giovarelli, Guido Forni

    Pages 231-247

The Ninth Annual Pezcoller Symposium entitled "The Biology of Tumors" was held in Rovereto, Italy, June 4-7, 1997. It focused on the genetic mechanisms underlying het­ erogeneity of tumor cell populations and tumor cell differentiation, on interactions be­ tween tumor cells and cells of host defenses, and the mechanisms of angiogenesis. With presentations at the cutting edge of progress and stimulating discussions, this symposium addressed issues related to phenomena concerned with cell regulation and cell interactions as determined by activated genes through the appropriate and timely media­ tion of gene products. Important methodologies that would allow scientists to measure dif­ ferentially genes and gene products and thus validate many of the mechanisms of control currently proposed were considered, as were the molecular basis of tumor recognition by the immune system, interactions between cells and molecular mechanisms of cell regula­ tion as they are affected by or implemented through these interactions. The molecular and cellular mechanisms of tumor vascularization were also discussed. It was recognized that angiogenesis provides a potential site of therapeutic intervention and this makes it even more important to understand the mechanisms underlying it. We wish to thank the participants in the symposium for their substantial contribu­ tions and their participation in the spirited discussions that followed. We would also like to thank Drs.

• DNA
• Microarray
• biology
• gene expression
• genes
• signal transduction
• transcription

• Roswell Park Cancer Institute, Buffalo, USA

  Enrico Mihich

• Kimmel Cancer Institute, Philadelphia, USA

  Carlo Croce

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