Clinical Application of Radiolabelled Platelets

1. Front Matter

   Pages i-xii

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2. Platelet Labelling Techniques

   1. Thromboembolism and Radiolabelled Platelets

      • M. C. Thakur

      Pages 1-6

   2. Platelet Isolation Technique and Viability Testing

      • M. R. Hardeman

      Pages 7-25

   3. Imaging Thrombus with Radiolabelled Monoclonal Antibody to Platelets

      • J. P. Lavender, A. M. Peters, A. W. J. Stuttle, S. G. Needham, I. Loutfi, D. Snook et al.

      Pages 26-27

   4. Haemodilution Improves III-in-Platelet Labelling Efficiency

      • D. A. J. Galvin, A. C. Meek, R. A. Harper, C. N. McCollum

      Pages 28-32

   5. Tc-99m HMPAO as a Potential Platelet Labelling Compound: First in Vivo and in Vitro Results

      • W. Becker, U. Borst, M. Weppler, E. P. Kromer, W. Burner

      Pages 33-44

   6. Platelet Labelling with III-in-Tropolonate

      • H. Louwes, J. J. Schuur

      Pages 45-60

3. Radiolabelled Platelets in Cardiology

   1. Radiolabelled Platelets in Cardiovascular Diseases

      • Mrinal K. Dewanjee

      Pages 61-110

   2. Dual Isotope Subtraction Platelet Scintigraphy in the Diagnosis of Left Ventricular Thrombosis

      • W. A. Freek, M. D. Verheugt, J. Albert, M. D. Funke-Kupper

      Pages 111-115

   3. Failure of Sulfinpyrazone to Prevent Left Ventricular Thrombosis in Patients with Acute Myocardial Infarction Treated with Oral Anticoagulants: A Randomized Trail in 100 Patients

      • A. J. Funke-Kupper, F. W. A. Verheugt, W. den Hollander

      Pages 116-127

   4. Cardiac Indium-III Platelet Scintigraphy in Stroke Patients

      • M. Rosch, H. Bihl, R. Reuther, H. Henningsen, Ch. Kessler

      Pages 128-136

4. Monitoring of Antiplatelet Therapy

   1. Monitoring of Antithrombotic Therapy with Radiolabelled Platelets

      • H. Sinzinger, P. Fitscha

      Pages 137-161

   2. Use of Dual Isotope Platelet Scintigraphy for Monitoring Antiplatelet Therapy in Stroke Patients

      • P. Voosen, Ch. Kessler, M. Hipp, J. N. Petrovici

      Pages 162-166

   3. The Evaluation of a New Specific Thromboxane A2 Antagonist on Radiolabelled Platelet Disposition in Prosthetic Grafts

      • A. C. Meek, R. A. Harper, I. F. Lane, C. N. McCollum

      Pages 167-172

5. Platelet Scintigraphy in Stroke Patients

   1. Platelet Scintigraphy in Stroke Patients

      • M. Goldman

      Pages 173-179

   2. Indium-111-Platelet Scintigraphy in Symptomatic and Asymptomatic Carotid Artery Disease. Preliminary Findings of a Prospective Study

      • E. B. Ringelstein, A. Wicke, M. Holken, G. Fiedler, C. Weiller, U. Bull

      Pages 180-194

   3. Radiolabelled Platelet Interactions with Damaged Endothelium in the Carotid Artery of Rabbits

      • A. C. Meek, D. A. J. Galvin, R. A. Harper, C. H. McCollum

      Pages 195-203

   4. Healing Following Carotid Endarterectomy Measured By 111-in Platelet Uptake

      • A. C. Meek, A. D. Chidlow, P. M. Jarvis, C. N. McCollum

      Pages 204-209

   5. Tc-99m-Labeled Autologous Platelets as Screening in Patients with Cerebrovascular Disease

      • M. Brenner, R. Berberich, A. Haass, G. Huber, H. Jäger

      Pages 210-213

6. Platelet Scintigraphy in Angiology

   1. Indium-III Labelled Platelet Imaging of Prosthetic Materials in Humans

      • J. R. Stratton

      Pages 214-234

AIMS OF THE COLOGNE-SYMPOSIUM ON RADIOLABELLED PLATELETS In 1976, M. Thakur et al (1) were the first to publish a paper concerning the in vivo thrombus detection with 111- In-labelled platelets. Previous attempts at scintigraphic thrombus localisation had been disappointing because of the unspecific binding of a number of the isotopes used, as well as the poor labelling efficiency or an insufficient low gamma-emitting property. Because of its physical characteristics (2.8 days half-life, 94% gamma emission) 111 Indium turned out to be the best isotope for platelet kinetic studies as well as for the measurement of platelet incorporation by Thrombi to be used up until now. The lipophile complexes of Ill-In (8-hydroxyquinoline, acetylacetone, tropolone) diffuse passively into the platelets without altering the function or the life span of the platelets. This advantage has let to an increase in the clinical applications of 1211-In labelled platelets. Today, radiolabelled platelets are used for thrombus detection in several different medical areas such as cardiology, nephrology. angiology or neurology. Even though many scientists and hospital doctors now routinely use radiolabelled platelet as a diagnostic tool, there is as yet not a standardized labelling method. In addition to this, there are neither standardized image procedures for the different clinical applications nor an agreement about specificity and sensitivity of the method. In 1983, a symposium on Radiolabelled Cellular Blood Elements was organized by M.Thakur, M.R.Hardeman and M.D.

• Scintigraphy
• cardiology
• cardiovascular
• diagnosis
• embolism
• imaging
• sepsis
• stroke
• thrombosis
• transplantation
• vascular disease

• Department of Neurology, Medical University Lübeck, Lübeck, Germany

  Ch. Kessler

• Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

  M. R. Hardeman

• Department of Neurology, University of Heidelberg, Heidelberg, Germany

  H. Henningsen

• Department of Neurology, Cologne-Merheim Hospital, Cologne, Germany

  J.-N. Petrovici

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