Logo - springer
Slogan - springer

Medicine - Nuclear Medicine | Imaging of Hypoxia - Tracer Developments

Imaging of Hypoxia

Tracer Developments

Machulla, Hans-Jürgen (Ed.)

1999, XX, 180 p.

Available Formats:
eBook
Information

Springer eBooks may be purchased by end-customers only and are sold without copy protection (DRM free). Instead, all eBooks include personalized watermarks. This means you can read the Springer eBooks across numerous devices such as Laptops, eReaders, and tablets.

You can pay for Springer eBooks with Visa, Mastercard, American Express or Paypal.

After the purchase you can directly download the eBook file or read it online in our Springer eBook Reader. Furthermore your eBook will be stored in your MySpringer account. So you can always re-download your eBooks.

 
$149.00

(net) price for USA

ISBN 978-94-017-1828-8

digitally watermarked, no DRM

Included Format: PDF

download immediately after purchase


learn more about Springer eBooks

add to marked items

Hardcover
Information

Hardcover version

You can pay for Springer Books with Visa, Mastercard, American Express or Paypal.

Standard shipping is free of charge for individual customers.

 
$189.00

(net) price for USA

ISBN 978-0-7923-5529-8

free shipping for individuals worldwide

usually dispatched within 3 to 5 business days


add to marked items

Softcover
Information

Softcover (also known as softback) version.

You can pay for Springer Books with Visa, Mastercard, American Express or Paypal.

Standard shipping is free of charge for individual customers.

 
$189.00

(net) price for USA

ISBN 978-90-481-5157-8

free shipping for individuals worldwide

usually dispatched within 3 to 5 business days


add to marked items

Hypoxia, i.e. insufficient availability of oxygen within the tissue, is a more serious problem than realized in clinical routine work, although a large variety of theoretical and experimental data give clearly proven indications. During incidences and progress of many types of diseases hypoxia may enhance development and progress of the disease and, furthermore, decrease chances of efficient treatment of, e.g., tumors. Hypoxic tumor cells are up to three times more resistant towards radiation therapy than normoxic cells. With a diagnostic tool such as provided by hypoxia tracers suitable for PET and SPECT imaging, the particular tissue situation becomes detectable and, thus, treatable. Although the clinical importance of hypoxia imaging is obviously great, to date neither the clinical nor the scientific community at an international level has focused many research activities on the hypoxia problem.
As the result of a workshop held by the Section for Radiopharmacy in Tübingen, this book collects observations and findings in order to stimulate the on-going research resulting in important clinical applications. Hypoxia imaging is needed in areas of cardiology, neurology and oncology. Additional applications are to be expected in the field of diabetes, infections and organ transplantation. Therefore, the book addresses those who are basically involved in research in radiochemistry and radiopharmacy as well as those dealing with all biological aspects and facing direct clinical applications.

Content Level » Research

Keywords » SPECT - Tumor - cardiology - imaging - neurology - organ transplantation - positron emission tomography (PET) - radiation - transplantation

Related subjects » Nuclear Medicine - Radiology

Table of contents 

Preface. 1. Hypoxia: An Introduction; L.I. Wiebe, H.-J. Machulla. 2. The Biology of Technetium Based Hypoxic Tissue Localising Compounds; A.D. Nunn. 3. Basic Chemistry of 2-Nitroimidazoles (Azomycin Derivates); C.E. Müller. 4. Molecular Design Approaches of Hypoxia Tracers; G. Folkers, et al. 5. Syntheses of PET-Tracers for the Determination of Hypoxia; J. Grierson, M. Patt. 6. Quantifying Hypoxia with Radiolabeled Fluoromisonidazole: Pre-Clinical and Clinical Studies; J.S. Rasey, et al. 7. Detection of Liver Hypoxia by [18F]Fluoromisonidazole and Application in Liver Transplant Disorders; M. Piert, H.-J. Machulla. 8. The Evaluation of Hypoxia in Diabetes; J.R. Mercer. H. Liu. 9. Radiohalogenated Nitroimidazoles for Single-Photon Scintigraphic Imaging of Hypoxic Tissues; L.I. Wiebe.

Popular Content within this publication 

 

Articles

Read this Book on Springerlink

Services for this book

New Book Alert

Get alerted on new Springer publications in the subject area of Nuclear Medicine.