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The application of modern quantitative MR techniques is dramatically changing our understanding of how MS causes irreversible disability, making this a timely and important study
These techniques evidence that MS is not only a white matter disease and that neurodegeneration is an important aspect of it
In multiple sclerosis (MS), conventional magnetic resonance imaging (cMRI) has proved to be a valuable tool to increase diagnostic reliability and to monitor the efficacy of experimental treatment. However, cMRI has limited specificity and accuracy as to the most disabling aspects of the MS pathology, known to occur in and outside macroscopic lesions. Modern quantitative MR techniques have the potential to overcome the limitations of cMRI, and their application is dramatically changing our understanding of how MS causes irreversible disability. Written by world-renowned scientists, the volume is indispensable for anybody working in this field.
Background: 1 Neuropathological Advances in Multiple Sclerosis.- 2 Neurophysiology.- MRI Techniques to Assess Neurodegeneration: 3 Atrophy.- 4 T1 Black Holes and Gray Matter Damage.- 5 Magnetization Transfer Imaging.- 6 Perfusion MRI.- 7 Diffusion-Weighted Imaging.- 8 Proton MR Spectroscopy.- 9 Functional MRI.-Evaluation of MRI Outcomes: 10 Validation of MRI Surrogates.- 11 Defining Responders and Non-responders.-12 Predictive Models in Multimodal Imaging.- Lessons from other Neurodegenerative Diseases: 13 Alzheimer’s Disease.- 14 Other Neurodegenerative Conditions.- 15 Incorporation of Other Biomarkers.- Designing MS Trials for Neurodegeneration.- 16 Critical Review of Existing Trials.- 17 Design for the Next Trials of Neurodegeneration.- Subject Index