Normal-appearing White and Grey Matter Damage in Multiple Sclerosis

In the last few years, increasing effort has been devoted to better define the characteristics of tissue damage occurring outside MRI-visible lesions in patients with multiple sclerosis (MS) and, as a consequence, to improve our understanding of the disease pathobiology and of the mechanisms leading to the accumulation of irreversible disability. This book provides an updated review of the results obtained by leading research groups in this field. The potential clinical applications of what has been shown so far, as well as the areas for future research in the study of normal-appearing white and gray matter damage in MS are extensively discussed, making this book a valuable tool for clinical neurologists who are involved in the daily-life care of MS patients and for neuroscientists involved in MS research.

• Function MRI
• brain
• clinical application
• diffusion-tensor MRI
• functional magnetic resonance imaging (fMRI)
• magnetic resonance
• magnetic resonance imaging
• magnetic resonance imaging (MRI)
• magnetization transfer MRI
• multiple sclerosis

From the reviews:

"A large part of the text concerns the various magnetic resonance (MR) techniques which have been investigated for use as tools for quantification of the heterogeneous pathological change in multiple sclerosis (MS). The editors have brought together authors from the discipline of neuropathology, neurology and MRI to summarize their work. … A great deal of information is clearly and accurately presented. … This book is aimed at neuroscientists … . It may also be of interest to those treating patients with MS." (A. Campi, Neuroradiology, Vol. 48 (2), 2006)

• Department of Neurology Scientific Institute, University Ospedale San Raffaele, Milan, Italy

  Giancarlo Comi

• Neuroimaging Research Unit Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy

  Massimo Filippi, Marco Rovaris

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