Disorders of Sleep and Wake in Parkinson's Disease
Videnovic, Aleksandar, Högl, Birgit (Eds.)
2015, Approx. 250 p. 60 illus., 10 illus. in color.
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First book dedicated to the topic of sleep dysfunction in Parkinson's disease
Provides a comprehensive and up-to-date overview of the field
With contributions from leading international experts
Impaired sleep and alertness is a major non-motor manifestation of Parkinson's disease (PD). Sleep dysfunction, which affects up to 90% of patients with Parkinson's disease, remains under-reported by patients and under-diagnosed by physicians and health professionals. Recently, sleep dysfunction has increasingly been recognized as a risk factor for development of Parkinson's disease.
Disorders of Sleep and Wake in Parkinson's Disease is the first book to take into account the rapidly accumulating knowledge related the interface of sleep and PD. With contributions from internationally recognized experts, the book is a single source of in-depth information on sleep and circadian dysregulation in Parkinson's disease. It is divided into two parts: the first comprises chapters summarizing normal sleep-wake homeostasis, followed by changes that occur in PD and discussions of available tools for the assessment of sleep-wake cycles in PD. In the second part, sleep and circadian disorders associated with PD are being described in individual chapters, including sections on epidemiology, etiology, pathogenesis, differential diagnosis, and treatment. Controversies in the field, such as the interface of cognition and sleep, fatigue and sleepiness, as well as the potential impact of surgical therapies on sleep-wake cycles will be discussed separately. The book concludes with a chapter on future directions and unmet needs in the field of sleep, circadian biology and PD.
This comprehensive text is readily accessible to both clinicians and researchers and addresses neurologists, sleep and movement disorders specialists, and all trainees as well as allied health professionals involved in the care of patients affected by Parkinson's Disease.
Part I.- 1. Introduction: Sleepy days and restless nights of Parkinson's Disease.- 2. Regulation of sleep and wake homeostasis.- 3. Neurochemistry of the sleep-wake cycle in Parkinson's disease.- 4. Impaired sleep and alertness in Parkinson's disease: what did we learn from animal models?.- 5. Objective measures of the sleep-wake cycle in Parkinson's disease.- 6. Subjective assessment of sleep and sleepiness in Parkinson's disease.
Part II.- 7. Excessive daytime somnolence associated with Parkinson's disease.- 8. Insomnia in Parkinson's disease.- 9. Sleep-disordered breathing in Parkinson's disease.- 10. Restless legs syndrome and periodic limb movement disorder in Parkinson's disease.- 11. REM sleep behavior disorder.- 12. REM sleep behavior disorder: a pre-motor marker of Parkinson's disease.- 13. Dysregulation of circadian system in Parkinson's disease.- 14. Cognition and the sleep-wake cycle in Parkinson's disease.- 15. Fatigue and sleepiness in Parkinson's disease.- 16. Impact of surgical therapies on sleep and alertness in Parkinson's disease.- 17. Future directions.