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Medicine - Neurology | Multiple System Atrophy

Multiple System Atrophy

Wenning, Gregor K., Fanciulli, Alessandra (Eds.)

2014, XVI, 198 p. 33 illus., 20 illus. in color.

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  • Provides complete insight into onset, progression, diagnoses and therapy of MSA
  • Summarizes the important advances gained in the last years in MSA research
  • Describes novel findings in MSA research and its therapies
This textbook provides a comprehensive monography on multiple system atrophy (MSA), a rare and fatal neurodegenerative disorder that presents with autonomic failure and either parkinsonism (MSA-P) or cerebellar ataxia (MSA-C).The underlying neuropathology of MSA is characterized by striatonigral degeneration (SND), olivopontocerebellar atrophy (OPCA) and unique oligodendroglial cytoplasmic alpha-synuclein inclusions. MSA is therefore classified among the alpha-synucleinopathies such as Parkinson`s disease, pure autonomic failure and dementia with Lewy bodies. Over the last decade there have been important advances in early diagnosis, pathogenesis research and clinical trial activity. The monography will cover the entire spectrum ranging from molecular and genetic work to symptomatic and interventional therapies. The book is written for movement disorder clinicians and basic neuroscientists interested in degenerative movement disorders.

Content Level » Professional/practitioner

Keywords » Alpha-synucleinopathies - Movement Disorders - Neurodegeneration - Parkinson┬┤s Disease - Substantia Nigra

Related subjects » Neurology - Neuroscience

Table of contents 

1. Historical Review.- 2. Epidemiology.- 3. Neuropathology.- 4. Etiopathogenesis.- 5. Animal Models.- 6. Clinical Presentation.- 7. Clinical diagnostic Criteria.- 8. Natural History.- 9. Investigations.- 10. Tratment.

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