Retrotransposition, Diversity and the Brain

1. Front Matter

   Pages I-XII

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2. Telomeres and Telomerase in Human Health and Disease

   • Jue Lin, Elissa S. Epel, Elizabeth H. Blackburn

   Pages 1-12

3. Molecular and Circuit Mechanisms for Hippocampal Learning

   • Susumu Tonegawa, Thomas J. McHugh

   Pages 13-19

4. Retrotransposons – Natural and Synthetic

   • Jef D. Boeke, Wenfeng An, Lixin Dai, Edward S. Davis, Jeffrey S. Han, Kathryn A. O’Donnell et al.

   Pages 21-32

5. Ancient Retrotransposons as Possible Remnants of the Primitive RNPWorld

   • Roland Ivanyi-Nagy, Jean-Luc Darlix

   Pages 33-42

6. Human Diversity and L1 Retrotransposon Biology: Creation of New Genes and Individual Variation in Retrotransposition Potential

   • H.H. Kazazian, M.d.C Seleme, D.V Babusho, D.M. Ostertag, M.R. Vetter, P.K. Mandal

   Pages 43-52

7. From the “RNAWorld” to Brain Complexity: Generation of Diversity

   • Alysson R. Muotri, Maria C.N. Marchetto, Fred H. Gage

   Pages 53-64

8. Endogenous Retroviruses and Human Neuropsychiatric Disorders

   • Robert H. Yolken, Håkan Karlsson, Ioannis Bossis, Linnéa Asp, Faith Dickerson, Christoffer Nellåker et al.

   Pages 65-85

9. Is Psychosis Due to Retroviral/Retrotransposon Integration Close to the Cerebral Dominance Gene?

   • T.J. Crow, J.S. Close, H.-S. Kim, M.T. Ross

   Pages 87-108

10. Microcephalies and DNA Repair

    • Edward C. Gilmore, Christopher A. Walsh

    Pages 109-120

11. Back Matter

    Pages 121-123

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The human brain is remarkably complex, permitting sophisticated behavioural rep- toires, such as languages, tool use, self-awareness, symbolic thought, cultural learning and consciousness. Each human being is different, due in part to the uniqueness of the neuronal heterogeneity and interconnections in our brains. Brain complexity and neuronal diversity are strongly related. The diversity of single neurons provides the underpinnings for how neuronal circuits operate. How and when neuronal diversity is generated, both in embryonic and adult neurogenesis, remain unknown. In the immune system, the highly diverse array of antigen receptors can be - tributed to the stochastic nature of the recombination process in somatic precursor cells, causing permanent changes in DNA and gene expression. This diverse population is then the target of selective processes that favor the correct antigen-receptor match and eliminate those with inadequate speci?cities, accounting for the rapid kinetics and immense diversity observed in vivo. Evidence for a possible similarity between the nervous and immune systems came from studies with mice de?cient in DNA double strand break (DSB) repair. Lessons learned from the discovery of the mechanism for diversityinthe immune system maybe usefultothe investigation ofthe mechanism of diversity in neurons.

• DNA
• DNA repair
• Telomere
• endogenous retroviruses
• genes
• microcephalies
• neuropsychiatric disorders
• retrotransposons
• telomeres

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