Neuropathology Simplified

This book provides the reader with an up-to-date, practical and succinct overview of basic neuropathology. It does not replace large reference textbooks in neuropathology but emphasizes key concepts and basic principles including recent advances, genetics and classification, and discusses important aspects of specific neuropathological disorders. It also gives practical hints on aspects of neuropathology, including how to best use the neuropathology service and interpret the results of pathological tests. The reader will gain a sufficiently broad basic knowledge of neuropathology which will be of use in their future clinical careers.

Neuropathology Simplified is aimed at trainees and residents in neurology, neurosurgery and psychiatry around the world. It may also be of use to basic scientists involved in neuroscience research and also to general histopathology trainees and residents.

• Interpret neuropathological test
• basic neuropathology
• clinico-pathologic correlation
• neuropathological disorder
• neuropathology

• Cellular & Anatomical Pathology Level 4, Derriford Hospital, Plymouth, United Kingdom

  David A. Hilton, Aditya G. Shivane

David Hilton is an experienced diagnostic neuropathologist working in one of the UK’s largest hospitals in Plymouth and is a fellow of both the UK Royal College of Pathologists and Physicians. His practice covers all areas of adult neuropathology, including neurosurgical pathology, autopsy work, and neuromuscular disease (including the undertaking of muscle and nerve biopsies on patients). In addition he is actively involved in research, including aspects of neurodegenerative disease and tumour biology, and has published over 85 peer reviewed research articles and written several book chapters, covering many aspects of neuropathology.

Selected publications:

Schwannomas and their pathogenesis. D.A.Hilton, C.O.Hanemann. Brain Pathology 2014; 24(3): 205-20.

Accumulation of alpha synuclein in the bowel of patients in the pre-clinical phase of Parkinson’s disease. D.A.Hilton, M.Stephens, L.Kirk, P.Edwards, R.Potter, J.Zajicek, E.Broughton, H.Hagan, C.Carroll. Acta Neuropathologica 2014; 127(2): 235-41.

Dipeptide repeat pathology in a frontotemporal dementia kindred with C9ORF72 mutation and intellectual disability. M.Proudfoot, N.J.Gutowski, D.Edbauer, D.A.Hilton, M.Stephens, J.Rankin, I.R. A.Mackenzie. Acta Neuropathologica 2014; 127(3):451-8.

Axl/Gas6/NFκB signalling in schwannoma pathological proliferation, adhesion and survival. S.Ammoun, L.Provenzano, L., M.C.Schmid, L.Zhou, M.Barczyk, K.Evans, D.A.Hilton, S.Hafisi, C.O.Hanemann. Oncogene 2014; 33(3): 336-46.

Quantification of mitochondrial changes in muscle from individuals without muscle disease; comparison with mitochondrial disorders. K.Sleigh, S.Ball, D.A.Hilton. Muscle and Nerve 2011; 46(6): 795-800.

Aditya Shivane has been working as a Consultant Neuropathologist in Derriford Hospital, Plymouth since 2009. He graduated from India in 1998. After completing post-graduation (MD, taught) in Pathology from Mumbai University (2001) he worked briefly as a Senior Registrar in the Department of Neuropathology at the National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India, before coming to the UK to undertake specialist Neuropathology training in Leeds. He became a fellow of the Royal College of Pathologists in 2008. His areas of interest include CNS tumours, neuromuscular disorders and ophthalmic pathology. He is actively involved in teaching neuropathology to undergraduate and postgraduate students and serves as an academic tutor at the Plymouth University Peninsula Schools of Medicine and Dentistry (PUPSMD).

Selected publications:

Loss of SOX10 function contributes to the phenotype of human Merlin-null schwannoma cells. Doddrell RD, Dun XP, Shivane A, Feltri ML, Wrabetz L, Wegner M, Sock E, Hanemann CO, Parkinson DB. Brain 2013;136(2):549-63.

Expression of c-Jun and Sox-2 in human schwannomas and traumatic neuromas. Shivane A, Parkinson DB, Ammoun S, Hanemann CO. Histopathology 2013;62(4):651-6.

Macrophagic myofasciitis: a report of second case from UK. Shivane A, Hilton DA, Moate RM, Bond PR, Endean A. Neuropathol Appl Neurobiol 2012;38(7):734-6.

Occurrence and distribution of pilomyxoid astrocytoma. Bhargava D, Sinha P, Chumas P, Al-Tamimi Y, Shivane A, Chakrabarty A, Surash S, Novegno F, Crimmins D, Tyagi AK. Br J Neurosurg 2013;27(4):413-8.

Twenty year review of histopathological findings in enucleated/eviscerated eyes. Saeed MU, Chang BY, Khandwala M, Shivane AG, Chakrabarty A. J Clin Pathol 2006;59(2):153-5.

Cysticercal chronic basal arachnoiditis with infarcts, mimicking tuberculous pathology in endemic areas. Aditya GS, Mahadevan A, Santosh V, Chickabasaviah YT, Ashwathnarayanarao CB, Krishna SS. Neuropathology 2004;24(4):320-5.

Policies and ethics