Dementia in Parkinsonism

1. Front Matter

   Pages i-vi

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2. The language of the basal ganglia

   • G. Stern

   Pages 1-8

3. Aging and the nigro-striatal pathway

   • F. F. Cruz-Sánchez, A. Cardozo, C. Castejón, E. Tolosa, M. L. Rossi

   Pages 9-25

4. Psychiatric symptoms and behavioural disturbances in the dementias

   • A. Burns

   Pages 27-35

5. PET and the investigation of dementia in the parkinsonian patient

   • N. Turjanski, D. J. Brooks

   Pages 37-48

6. Neurofibrillary tangles and neuropil threads as a cause of dementia in Parkinson’s disease

   • H. Braak, E. Braak, D. Yilmazer, R. A. I. de Vos, E. N. H. Jansen, J. Bohl

   Pages 49-55

7. Morphological substrates of dementia in parkinsonism A critical update

   • K. A. Jellinger

   Pages 57-82

8. The Lewy body variant of Alzheimer disease

   • L. A. Hansen

   Pages 83-93

9. Lewy body dementia — clinical, pathological and neurochemical interconnections

   • R. Perry, I. McKeith, E. Perry

   Pages 95-109

10. Pathological diagnostic criteria for dementia associated with cortical Lewy bodies: review and proposal for a descriptive approach

    • J. Lowe, D. Dickson

    Pages 111-120

11. Pathology of familial Alzheimer’s disease with Lewy bodies

    • T. Revesz, J. L. McLaughlin, M. N. Rossor, P. L. Lantos

    Pages 121-135

12. Amyloid ß-peptide and its relationship with dementia in Lewy body disease

    • K. Jendroska, M. Kashiwagi, J. Sassoon, S. E. Daniel

    Pages 137-144

13. Neurochemical abnormalities in Alzheimer’s disease and Parkinson’s disease — a comparative review

    • W. Gsell, I. Strein, U. Krause, P. Riederer

    Pages 145-159

14. Apolipoprotein E gene in Parkinson’s disease, Lewy body dementia and Alzheimer’s disease

    • D. St. Clair

    Pages 161-165

15. Indices of oxidative stress in Parkinson’s disease, Alzheimer’s disease and dementia with Lewy bodies

    • A. D. Owen, A. H. V. Schapira, P. Jenner, C. D. Marsden

    Pages 167-173

16. Treatment of behavioural disturbances in Parkinson’s disease

    • F. Valldeoriola, F. A. Nobbe, E. Tolosa

    Pages 175-204

In his original essay on the shaking palsy (1817) James Parkinson remarked that the "senses and intellect were uninjured". Thus, it was only in later years that the complexity ofparkinsonism and in particular Parkinson's disease with dementia was recognised. Cognitive impairment in Parkinson's disease is common and is estimated to affect more than forty per cent of patients with disease onset after age 65. Recent studies suggest that pathology of Parkin­ son's disease now ranks second to Alzheimer's disease as the commonest sub­ strate of dementia in elderly patients. The condition is heterogeneous and there remain many complicated and unresolved questions concerning cause, diagnosis and classification. In an attempt to clarify these issues, scientists and members of the European Brain Bank Network (EBBN) gathered in London for a meeting entitled "Dementia in Parkinsonism". The resultant monograph is testimony to the wide-ranging clinical, morphological and biochemical aspects of this condition. We are grateful to all contributors for expressing their expert opinions and for being so generous with their time taken in prepa­ ration of the manuscripts. The meeting was funded by the Commission of the European Communities as part of a Biomed-l Programme. We wish to thank Amgen Limited, Lilly Industries Limited and Roche Products Limited for additional sponsorship. The expert secretarial assistance of R. Nani in the pre­ paration of this book has been very much appreciated. London, November 1997 S. E. Daniel F. F. Cruz-Sanchez A. J. Lees Contents Stern, G. : The language of the basal ganglia . . . . . . . . . . . . . . . . . . . . . .

• Alzheimer
• Lipoprotein
• PET
• Parkinson
• alzheimer's disease
• brain
• dementia
• diagnosis
• oxidative stress
• positron emission tomography (PET)
• research
• stress

• Parkinson’s Disease Society Brain Research Centre (Brain Bank), Institute of Neurology, London, UK

  S. E. Daniel, A. J. Lees

• Neurological Tissue Bank, Hospital Clinic, University of Barcelona, Spain

  F. F. Cruz-Sánchez

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