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Clinical Trials in Neurology

  • Book
  • © 2001

Overview

Editors:
  1. Roberto J. Guiloff

    1. Neuromuscular Unit, West London Neurosciences Centre, 1st Floor Pilot Wing, Charing Cross Hospital, London, UK

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  • Drug companies rely on trials to show the efficacy or problems relating to new drugs
  • This new multi-contributor book aims to improve the efficacy of neurological trials by improving trial design

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About this book

Clinical Trials in Neurology comprehensively tackles the methodology and design of clinical trials in neurological disease. A general section deals with the ethical aspects, drug development and regulatory requirements, basic trial designs and the statistics used. A diseases section tackles specific aspects of disorders, focusing on the relevant ethical issues, outcome variables and experience with large multicentre trials.

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Table of contents (41 chapters)

  1. Front Matter

    Pages i-xvii
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  2. General

    1. Front Matter

      Pages 1-1
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    2. Ethical Considerations

      • T. Hope, J. Savulescu
      Pages 3-15

    3. Assessment Measures and Clinical Scales

      • J. C. Hobart, A. J. Thompson
      Pages 17-28

    4. Ethics, Outcome Variables and Clinical Scales: The Clinician’s Point of View

      • E. Buskens, J. van Gijn
      Pages 29-41

    5. The Cochrane Collaboration Reviews in Neurology

      • L. Candelise
      Pages 43-51

    6. Drug Development Stages

      • T. G. K. Mant
      Pages 53-58

    7. Drug Regulatory Requirements in the United Kingdom and Europe

      • D. B. Jeffreys
      Pages 59-69

    8. Drug Regulatory Requirements in the United States

      • P. Leber
      Pages 71-80

    9. Quality Control and Data Monitoring: A Guide to Good Clinical Practice

      • L. Brown
      Pages 81-94

    10. Statistical Issues in Clinical Trials in Neurology

      • S. Senn
      Pages 95-103

    11. Analysis of Results: Statistical Principles

      • D. Hoberman, J. T. Sahlroot
      Pages 105-120

    12. Survival Analysis

      • R. Newson
      Pages 121-129

    13. The Intention-to-Treat Principle for Clinical Trials

      • M. J. Schell, M. A. McBride, C. Gennings, G. G. Koch
      Pages 131-143

    14. Statistical Analysis of Repeated-Measures Data with Drop-outs

      • R. J. Little
      Pages 145-156

    15. The Role of Meta-analyses in Clinical Research: Uses and Limitations

      • L. A. Stewart
      Pages 157-168

  3. Diseases

    1. Front Matter

      Pages 169-169
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    2. Outcome Variables in Dementia Trials: Conceptual and Practical Issues

      • A. D. Lawrence, B. J. Sahakian
      Pages 171-182

    3. Dementia: Trial Design and Experience with Large Multicentre Trials

      • R. J. Harvey, M. N. Rossor
      Pages 183-198

    4. Cerebrovascular Disease: Basic Designs, Sample Sizes and Pitfalls

      • P. M. Rothwell
      Pages 199-212
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Editors and Affiliations

  • Neuromuscular Unit, West London Neurosciences Centre, 1st Floor Pilot Wing, Charing Cross Hospital, London, UK

    Roberto J. Guiloff

Bibliographic Information

  • Book Title: Clinical Trials in Neurology

  • Editors: Roberto J. Guiloff

  • DOI: https://doi.org/10.1007/978-1-4471-3787-0

  • Publisher: Springer London

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag London 2001

  • Hardcover ISBN: 978-1-85233-239-6Published: 05 May 2001

  • Softcover ISBN: 978-1-84996-856-0Published: 13 October 2010

  • eBook ISBN: 978-1-4471-3787-0Published: 14 March 2013

  • Edition Number: 1

  • Number of Pages: XVIII, 542

  • Topics: Neurology, Pharmacology/Toxicology

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