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Autism

Current Theories and Evidence

  • A state-of-the-art synthesis of credible biological theories of autism and the evidence that supports them
  • Unique, evidence-based review of pathogenesis, clinical features, and current or potential treatments
  • Wide-ranging, covering six main areas that probe and reveal the biological bases of autistic spectrum disorders
  • Chapters cover molecular and clinical genetics; neurotransmitters and cell signaling; endocrinology, growth, and metabolism; immunology, maternal-fetal effects, and neuroinflammation; neuroanatomy, imaging, and neural networks, and environmental mechanisms and models

Part of the book series: Current Clinical Neurology (CCNEU)

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-xix
  2. Molecular and Clinical Genetics

    1. Front Matter

      Pages 1-1
    2. Teratogenic Alleles in Autism and Other Neurodevelopmental Disorders

      • William G. Johnson, Madhura Sreenath, Steven Buyske, Edward S. Stenroos
      Pages 41-68
    3. Autism in Genetic Intellectual Disability

      • Walter E. Kaufmann, George T. Capone, Megan Clarke, Dejan B. Budimirovic
      Pages 81-108
  3. Neurotransmitters and Cell Signaling

    1. Front Matter

      Pages 109-109
    2. Serotonin Dysfunction in Autism

      • Mary E. Blue, Michael V. Johnston, Carolyn B. Moloney, Christine F. Hohmann
      Pages 111-132
    3. Excitotoxicity in Autism

      • Martin Evers, Eric Hollander
      Pages 133-145
  4. Endocrinology, Growth, and Metabolism

    1. Front Matter

      Pages 183-183
    2. A Role for Fetal Testosterone in Human Sex Differences

      • Bonnie Auyeung, Simon Baron-Cohen
      Pages 185-208
    3. Insulin-Like Growth Factors

      • Raili Riikonen
      Pages 233-244
  5. Immunology, Maternal-Fetal Interaction, and Neuroinflammation

    1. Front Matter

      Pages 269-269
    2. The Immune System in Autism

      • Luke Heuer, Paul Ashwood, Judy Van de Water
      Pages 271-288
    3. Maternal Immune Activation, Cytokines and Autism

      • Paul H. Patterson, Wensi Xu, Stephen E.P. Smith, Benjamin E. Devarman
      Pages 289-307
    4. Maternal Antibodies and the Placental–Fetal IgG Transfer Theory

      • Christina M. Morris, Mikhail Pletnikov, Andrew W. Zimmerman, Harvey S. Singer
      Pages 309-328

About this book

Creative thinking and collaborative scientific research have advanced our understanding of autism, and we are now beginning to synthesize the data into evidence and theories. Autism: Current Theories and Evidence presents current theories about autism and the evidence that supports them. The goal is to show how the scientific method is revealing the biological bases of this spectrum of disorders, thereby leading the way to their treatment and prevention using evidence-based medicine. This book has 20 chapters divided into 6 sections: Molecular and Clinical Genetics; Neurotransmitters and Cell Signaling; Endocrinology, Growth and Metabolism; Immunology, Maternal-Fetal Effects and Neuroinflammation; Neuroanatomy, Imaging and Neural networks; and Environmental Mechanisms and Models. The subjects cover a wide range of current scientific work in the field of autism, with strong and growing evidence to support them, and demonstrate both the breadth and depth of current autism research. The reader is encouraged to consider how theories and the scientific method, in the hands of these and other dedicated researchers, are leading to greater knowledge and continued progress in autism research.

Reviews

From the reviews:

"Autism: Current Theories and Evidence, edited by Andrew Zimmerman, serves as an atlas or geophysical study of the archipelago of autism. … this book is a valuable contribution to the effort to map autism, and it is a demonstration of the type of cooperation that is needed across scientific disciplines if progress is to be made in this effort." (Jeffrey A. Munson, The New England Journal of Medicine, Vol. 360 (23), June, 2009)

“All chapters are uniformely arranged with initial abstract, many informative subheadings, tables and impressive figures. All of them are clearly written … . the present book provides an impressive, evidence-based review of pathogenesis, clinical features, genetics, biological bases, pathogenetic factors, current or future treatments of ASDs. It is therefore recommended to all clinicians and neuroscientist who are interested and engaged in the complex field of ASDs.” (K. A. Jellinger, European Journal of Neurology, Vol. 16, 2009)

“The book has 20 chapters divided into 6 parts. … Mainly, but not only, for neurobiologists, psychologists and psychiatrists. Recommended.” (Pediatric Endocrinology Reviews, Vol. 8 (2), December, 2010)

Authors and Affiliations

  • Kennedy Krieger Institute and Johns Hopkins University, Baltimore, USA

    Andrew W. Zimmerman

Bibliographic Information

  • Book Title: Autism

  • Book Subtitle: Current Theories and Evidence

  • Authors: Andrew W. Zimmerman

  • Series Title: Current Clinical Neurology

  • DOI: https://doi.org/10.1007/978-1-60327-489-0

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Humana Press 2008

  • Hardcover ISBN: 978-1-60327-488-3Published: 15 October 2008

  • Softcover ISBN: 978-1-61737-901-7Published: 19 November 2010

  • eBook ISBN: 978-1-60327-489-0Published: 08 October 2008

  • Series ISSN: 1559-0585

  • Series E-ISSN: 2524-4043

  • Edition Number: 1

  • Number of Pages: XIX, 474

  • Number of Illustrations: 50 b/w illustrations, 8 illustrations in colour

  • Topics: Neurology, Neurosciences

Buy it now

Buying options

eBook USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access