Cortico-Subcortical Dynamics in Parkinson’s Disease

1. Front Matter

   Pages i-xiii

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2. Cortico-Subcortical Circuits and Parkinson’s Disease

   1. Front Matter

      Pages 1-1

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   2. Leading Toward a Unified Cortico-basal Ganglia Functional Model

      • Shannon R. Blume, Kuei Y. Tseng

      Pages 1-20

   3. Modeling Parkinson’s Disease: 50 Years Later

      • Gloria E Meredith, Kuei Y Tseng

      Pages 23-34

3. Physiological Studies of the Cortico-subcortical Dynamics and Parkinson’s Disease

   1. Front Matter

      Pages 1-1

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   2. Phasic Dopaminergic Signaling: Implications for Parkinson’s Disease

      • Stefan G. Sandberg, Paul E.M. Phillips

      Pages 37-54

   3. Striatal Dendritic Adaptations in Parkinson’s Disease Models

      • Michelle Day, D. James Surmeier

      Pages 55-71

   4. Diversity of Up-State Voltage Transitions During Different Network States

      • Nicolas Vautrelle, Luis Carrillo-Reid, José Bargas

      Pages 73-85

   5. The Corticostriatal Pathway in Parkinson’s Disease

      • Nigel S. Bamford, Carlos Cepeda

      Pages 87-104

   6. Cholinergic Interneuron and Parkinsonism

      • Dario Cuomo, Paola Platania, Giuseppina Martella, Graziella Madeo, Giuseppe Sciamanna, Annalisa Tassone et al.

      Pages 105-115

   7. Basal Ganglia Network Synchronization in Animal Models of Parkinson’s Disease

      • Judith R. Walters, Debra A. Bergstrom

      Pages 117-142

   8. Converging into a Unified Model of Parkinson’s Disease Pathophysiology

      • Camila L. Zold, Mariano Belluscio, Fernando Kasanetz, Pablo E. Pomata, Luis A. Riquelme, Francois Gonon et al.

      Pages 143-156

   9. The Corticostriatal Transmission in Parkinsonian Animals: In Vivo Studies

      • Bérangère Ballion, Nicolas Mallet, Catherine Le Moine, Mario Gustavo Murer, Francois Gonon

      Pages 157-169

   10. Striatal Nitric Oxide–cGMP Signaling in an Animal Model of Parkinson’s Disease

       • Anthony R. West, Stephen Sammut, Marjorie A. Ariano

       Pages 171-184

   11. Dopamine–Endocannabinoid Interactions in Parkinson’s Disease

       • Sarah E. McCallum, Joseph F. Cheer

       Pages 185-205

   12. Glutamate Plasticity in an Animal Model of Parkinson’s Disease

       • Charles K. Meshul

       Pages 207-230

4. Computational Analyses of the Cortico-Subcortical Dynamics and Parkinson’s Disease

   1. Front Matter

      Pages 1-1

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   2. Neuromodulation and Neurodynamics of Striatal Inhibitory Networks: Implications for Parkinson’s Disease

      • Tomomi Shindou, Gordon W. Arbuthnott, Jeffery R. Wickens

      Pages 233-243

   3. Dopaminergic Modulation of Corticostriatal Interactions and Implications for Parkinson’s Disease

      • John A. Wolf, Jason T. Moyer

      Pages 245-258

5. Neurobiology and Pathophysiology of Parkinson's Disease

   1. Front Matter

      Pages 1-1

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The striatum is the principal input structure of the basal ganglia. Numerically, the great majority of neurons in the striatum are spiny projection neurons, which produce the inhibitory output of the striatum to the globus pallidum and substantia nigra. The major glutamatergic afferents to the striatum from the cerebral cortex make monosynaptic contact with spiny projection neurons. The dopaminergic afferents from the substantia nigra also synapse directly on the spiny projection neurons. Thus, the spiny projection neurons play a crucial role in the input–output operations of the striatum by integrating glutamatergic cortical inputs with dopaminergic inputs and producing the output to other basal ganglia nuclei. Anatomical observations made nearly 30 years ago suggested that inhibitory interactions among the spiny projection neurons of the striatum are very pr- able. Individual spiny projection neurons produce a local axonal plexus in the spheroidal space occupied by their own dendritic trees [1, 2]. Based on the GABAergic nature of these neurons and their synaptic contacts with other spiny neurons, several authors have proposed that the spiny projection neurons form a lateral inhibition type of neural network [3–5]. In the idealised concept of lateral inhibition, each output neuron makes inhibitory synaptic contact with its neighbours [5]. However, there are physical limitations set by the extent of axonal and dendritic trees, and the number of synaptic sites, which mean that lateral inhibition is limited to a local domain of inhibition.

• Contemporary
• Cortico
• Disease
• Dynamics
• Neurology
• Neuroscience
• Parkinson
• Parkinson's
• Subcortical
• anatomy
• dopamine
• lead
• pathophysiology
• physiology

From the reviews:

"This book nicely combines up-to-date basic science information with clinical data on one of the most prevalent movement disorders worldwide - Parkinson’s disease (PD). … Written for specialists in Parkinson’s disease, the book is appropriate for movement disorder neurologists, neurosurgeons involved in the surgical management of Parkinson’s, and basic scientists interested in the anatomy, physiology, and neurochemistry of Parkinson’s. … It is most useful as a reference for basic scientists as well as clinical researchers." (Virgilio Gerald H. Evidente, Doody’s Review Service, September, 2009)

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