Overview
- Editors:
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V. A. Najjar
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Table of contents (24 chapters)
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- Michel Baudry, Gary Lynch
Pages 5-18
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- John J. McGuire, Joseph R. Bertino
Pages 19-48
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- M. J. W. Brennan, R. C. Cantrill
Pages 49-58
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- Mary Lynn Fink, J. E. Folk
Pages 59-67
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- Tage Honoré, Povl Krogsgaard-Larsen, Jan J. Hansen, Jørn Lauridsen
Pages 123-128
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- Povl Krogsgaard-Larsen, Erik Falch
Pages 129-146
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- Robert L. Macdonald, Anne B. Young
Pages 147-162
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- E. K. Michaelis, M. L. Michaelis, H. H. Chang, R. D. Grubbs, D. R. Kuonen
Pages 163-179
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- George N. Abraham, David N. Podell
Pages 181-190
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- John P. Burnier, Marianne Borowski, Barbara C. Furie, Bruce Furie
Pages 191-207
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- David J. Cichowicz, Siang K. Foo, Barry Shane
Pages 209-228
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- Jang-Yen Wu, Christopher Brandon, Y. Y. Thomas Su, Dominic M. K. Lam
Pages 229-238
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- Vivian I. Teichberg, Ora Goldberg, Alberto Luini
Pages 281-295
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About this book
the GABA increase takes place and (2) the area of the brain that may mediate the anticonvulsant Investigation of the physiology, biochemistry, activity. Three compounds that increase brain pharmacology and anatomy of GAB A and GABA GABA by distinct mechanisms were used in these containing neural systems, continues to reveal the studies: di-n-propylacetate (DPA, sodium val rich complexities associated with this neuroactive proate, Depakene(R)), amino-oxyacetic acid amino acid (see recent symposia 1,2,3). Advances (AOAA) and y-vinyl GABA (GVG). in the pharmacology of GABA-mimetic agents In the next sections, the metabolism of GABA have resulted in the development of compounds and a brief historical account of the relationship that can selectively activate GABA receptors (4,5, between GABA and anticonvulsant activity are 6, 7), inhibit the synthetic and degradative enzymes outlined followed by a discussion ofthe biochemical for GABA (8, 9) or affect the neuronal and glial and pharmacological effects of the three drugs. In uptake processes for GABA (10, 11). This has particular, the literature pertaining to the suppres already had a significant impact on our under sion of seizures and the correlation between anti standing of the role of GABA in convulsions and a convulsant action and increases in brain G ABA will range of other CNS functions including feeding be examined. (12), cardiovascular control (13), motor activity (14) and release of pituitary hormones (15). Before 1.