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Medicine - Internal Medicine | The Islets of Langerhans

The Islets of Langerhans

Islam, M. S. (Ed.)

2010, XXII, 800p.

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  • A long-awaited book on islets
  • Comprehensive coverage from currents and molecules to the bedside
  • In depth analysis of cutting edge research
  • Great ideas and directions for future research
  • Fundamental background information on islet research in a nutshell
When new fellows join my lab, I give them some reading materials so that they can orient themselves in their assignment in a new eld. When fellows leave my lab, some after writing their dissertations, I prefer to give them a book as a symbolic present. I was longing for a book that contained something on more or less eve- thing about the islets. At the same time, I wished it contained information as recent as possible. There are a few such books in the market but they are pretty outdated. I started picking islets myself from October 1990, when I joined the Rolf Luft Center, Karolinska Institutet. Over the years my fascination for islet research remained high. Since last year, I felt a stronger urge to do more for these mysterious and hidden mini-organs that are directly or indirectly involved in the pathogenesis of all forms of diabetes that affects ?250 million people in the world. After I launched the Islet (landesbioscience. com/journals/islets) and founded the Islet Society (isletso- ety. org), there was a momentum that could be utilized to create something equally meaningful i. e. this book. The idea cracked in September 2008. Starting September 19, 2008, I contacted an estimated 90% of the authors who published anything on the islets during 2007–2008 and who could be traced from the internet.

Content Level » Research

Keywords » Diabetes - Diabetes mellitus - Immunity - Insulin Secretion - Islets Of Langerhans - Pancreatic Islets - Proteomics - Vivo - cellular processes - insulin - regulation

Related subjects » Biomedical Sciences - Cell Biology - Internal Medicine

Table of contents 

CHAPTER 1 : Microscopic anatomy of the human islet of Langerhans - Peter In't Veld and Miriam Marichal CHAPTER 2 : The comparative anatomy of islets - Scott Heller CHAPTER 3: Approaches for imaging of islets: recent advances and future prospects - Ulf Ahlgren and Martin Gotthardt CHAPTER 4: Islet-cell Development - Anabel Rojas, Adrian Khoo, Juan R. Tejedo, Francisco J. Bedoya, Bernat Soria and Franz Martín CHAPTER 5: High fat programming of b-cell failure - Marlon. E. Cerf CHAPTER 6: Nutrient regulation of insulin secretion and b-cell functional integrity - Philip Newsholme, Celine Gaudel, and Neville H McClenaghan CHAPTER 7: Electrophysiology of islet cells - Gisela Drews, Peter Krippeit-Drews and Martina Düfer CHAPTER 8: ATP sensitive potassium channels in health and disease - Rebecca Clark and Peter Proks CHAPTER 9: Role of mitochondria in b-cell function and dysfunction - Pierre Maechler, Ning Li, Marina Casimir, Laurène Vetterli, Francesca Frigerio, Thierry Brun CHAPTER 10: Basement membrane in pancreatic islet function - Martin Kragl and Eckhard Lammert CHAPTER 11: Calcium signaling in the islets - Md. Shahidul Islam CHAPTER 12: Electrical bursting, calcium oscillations, and synchronization of pancreatic islets - Richard Bertram, Arthur Sherman, and Leslie S. Satin CHAPTER 13: Cyclic AMP signaling in pancreatic islets - Brian Furman, Wee Kiat Ong, and Nigel Pyne CHAPTER 14: Exocytosis in islet b-cells - Haruo Kasai, Hiroyasu Hatakeyama, Mitsuyo Ohno and Noriko Takahashi CHAPTER 15: The novel roles of glucagon-like peptide-1, angiotensin II, and vitamin D in islet function - Po Sing Leung CHAPTER 16: Proteomics and islets research - Meftun Ahmed CHAPTER 17: Wnt signaling in pancreatic islets - Zhengyu Liu and Joel F. Habener CHAPTER 18: Molecular pathways underlying the pathogenesis of pancreatic a-cell dysfunction - Dan Kawamori,Hannah J. Welters, and Rohit N. Kulkarni CHAPTER 19: Mechanisms of pancreatic b-cell apoptosis in diabetes and its therapies - James D. Johnson, Dan S. Luciani CHAPTER 20: b-cell function in obese-hyperglycaemic mice [ob/ob mice] - Per Lindström CHAPTER 21: Islet structure and function in the GK rat - B. Portha, G. Lacraz, A. Chavey, F. Figeac, M. Fradet, C. Tourrel-Cuzin, F. Homo-Delarche, M-H. Giroix, D. Bailbé, MN. Gangnerau, J. Movassat CHAPTER 22: The b-cell in human type 2 diabetes - Piero Marchetti, Roberto Lupi, Silvia Del Guerra, Marco Bugliani, Lorella Marselli and Ugo Boggi CHAPTER 23: Clinical approaches to preserve b-cell function in diabetes - Bernardo L. Wajchenberg CHAPTER 24: Immunology of b-cell destruction - Daria La Torre, and Åke Lenmark CHAPTER 25: Toll-like receptors and type 1 diabetes - Danny Zipris CHAPTER 26: Prevention of b-cell destruction in autoimmune diabetes: current approaches and future prospects - Saikiran K Sedimbi and Carani B Sanjeevi CHAPTER 27: In vivo regeneration of insulin-producing b-cell - Hee-Sook Jun CHAPTER 28: Customized cell-based treatment options to combat autoimmunity and restore b-cell function in Type I diabetes mellitus: current protocols and future perspectives - Fred Fändrich and Hendrik Ungefroren CHAPTER 29: The progammable cell of monocytic origin (PCMO): A potential adult stem/progenitor cell source for the generation of islet cells - Hendrik Ungefroren and Fred Fändrich CHAPTER 30: Islet isolation for clinical transplantation - Tatsuya Kin CHAPTER 31: Human islet autotransplantation: the trail thus far and the highway ahead - Martin Hermann, Raimund Margreiter and Paul Hengster CHAPTER 32: Modulation of early inflammatory reactions to promote engraftment and function of transplanted pancreatic islets in autoimmune diabetes - Lorenzo Piemonti, Luca G. Guidotti,

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