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Medicine - Internal Medicine | Autoimmune Liver Diseases - Perspectives from Japan

Autoimmune Liver Diseases

Perspectives from Japan

Ohira, Hiromasa (Ed.)

2014, VIII, 305 p. 70 illus., 44 illus. in color.

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  • Based on Japanese research findings in autoimmune liver diseases
  • Explains how Japanese patients with autoimmune hepatitis form a unique disease population as a result of their genetic background
  • Presents the latest findings in research and treatment of primary biliary cirrhosis patients, along with new pathological staging criteria

Autoimmune Liver Diseases summarizes the recent high-impact research and clinical findings obtained in Japan in the study and treatment of autoimmune liver diseases. Although these disorders are relatively rare, they are recognized as an important group of refractory liver diseases, the most common of which are autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC). The book therefore comprises two major sections, one dealing with AIH, the other with PBC.

AIH in Japanese patients creates a unique disease population, as its clinical features are different from those of Western patients resulting from the different genetic background of the two patient populations. Also, mouse models of neonatal thymectomy-PD-1 knockout mice, clinical analyses of acute hepatitis-like manifestations, and research findings on IgG4-related autoimmune hepatitis have been reported in Japan and are included in this book. A disease-susceptibility gene specific to Japanese PBC patients has also recently been discovered. Because of the relatively homogeneous population of Japan, analyses conducted with Japanese PBC patients have yielded findings that are highly relevant to the pathogenesis of the disease.

Furthermore, new pathological staging criteria, anti-gp210 antibodies and the basis they provide for improved accuracy of prognosis, treatment with bezafibrate, and the outcomes of living-donor liver transplantation are also presented here. This volume therefore serves as a useful resource not only for hepatologists, but also for researchers, clinical residents, and medical students both in Japan and in other countries.

Content Level » Professional/practitioner

Keywords » AIH - PBC - autoimmune hepatitis - primary biliary cirrhosis

Related subjects » Internal Medicine

Table of contents 

Preface.-

Part I Autoimmune Hepatitis.- 

1 Pathogenesis of Autoimmune Hepatitis-.

2 Animal Models of Autoimmune Hepatitis.-

3 Epidemiology and Natural History in Japan.-

4 Histological Findings of Autoimmune Hepatitis.-

5 Diagnosis of Autoimmune Hepatitis.-

6 Acute Presentation of Autoimmune Hepatitis.-

7 Treatment of Autoimmune Hepatitis.-

8 Management Strategies for Autoimmune Hepatitis Treatment Non-Responders.-

9 Pediatric Autoimmune Hepatitis.-

10 Nonalcoholic Steatohepatitis -Autoimmune Hepatitis Overlap.-

11 IgG4-Related Autoimmune Hepatitis.-

Part II Primary Biliary Cirrhosis.-

12 The Onset Mechanism of Primary Biliary Cirrhosis.-

13 Genetic Factors in Pathogenesis of Primary Biliary Cirrhosis.-

14 Animal Models of Primary Biliary Cirrhosis.-

15 Epidemiology and Natural History in Japan.-

16 New Histological Staging and Grading System for Primary Biliary Cirrhosis.-

17 Autoantibodies in Primary Biliary Cirrhosis.-

18 Diagnosis and UDCA Treatment of Primary Biliary Cirrhosis.-

19 Bezafibrate Treatment of Primary Biliary Cirrhosis.-

20 Management the Patients with Feature of Autoimmune Hepatitis.-

21 Liver Transplantation for Primary Biliary Cirrhosis   ​

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