Chronically Evolving Viral Hepatitis

1. Front Matter

   Pages i-xi

   PDF

2. Immune pathogenesis of viral hepatitis

   1. Front Matter

      Pages 1-1

      PDF

   2. Immune pathogenesis of hepatitis A

      • A. Vallbracht, B. Fleischer

      Pages 3-4

   3. Relapsing hepatitis A in Saimiri monkeys experimentally reinfected with a wild type hepatitis A virus (HAV)

      • S. Prevot, J. Marechal, J. Piilot, J. Prevot

      Pages 5-10

   4. Immune pathogenesis of hepatitis B

      • C. Ferrari, Amalia Penna, A. Bertoletti, A. Cavalli, A. Valli, G. Missale et al.

      Pages 11-18

   5. T cell recognition of hepatitis B envelope proteins

      • V. Barnaba, A. Franco, M. Paroli, R. Benvenuto, I. Santilio, F. Balsano

      Pages 19-22

   6. Fine specificity of the human T cell response to hepatitis B virus core antigen

      • Amalia Penna, A. Bertoletti, A. Cavalli, A. Valli, G. Missale, M. Pilli et al.

      Pages 23-28

   7. HBcAg induced T-cell independent anti-HBc production in chronic HBsAg carriers

      • S. P. E. Sylvan, U. B. Hellström, G. Fei, H. Norder, L. Magnius, G. Lindh

      Pages 29-35

   8. Divergent anti-HBc reactivities in HB-immune and chronic HBsAg carriers

      • U. B. Hellström, S. P. E. Sylvan

      Pages 36-38

   9. Absence of free core antigen in anti-HBc negative viremic hepatitis B carriers

      • Ch. Possehl, R. Repp, K.-H. Heermann, E. Korec, A. Uy, W. H. Gerlich

      Pages 39-41

   10. Homing of T-lymphocytes in acute and chronic HBV positive inflammatory liver disease

       • R. Volpes, J. J. van den Oord, V. J. Desmet

       Pages 42-45

   11. Hepatitis B virus specific transcripts in peripheral blood mononuclear cells

       • Margherita Melegari, P. P. Scaglioni, C. Pasquinelli, F. Manenti, Erica Villa

       Pages 46-49

   12. Detection of transcriptionally active hepatitis B virus DNA in peripheral mononuclear blood cells after infection during immunosuppressive chemotherapy using the polymerase chain reaction

       • R. Repp, A. Mance, C. Keller, S. Rhiel, W. H. Gerlich, F. Lampert

       Pages 50-53

3. Oncogenic properties of hepatitis viruses

   1. Front Matter

      Pages 55-55

      PDF

   2. The hepatitis B virus X protein transactivation of c-fos and c-myc proto-oncogenes is mediated by multiple transcription factors

      • M. L. Avantaggiati, C. Balsano, G. Natoli, E. De Marzio, H. Will, E. Elfassi et al.

      Pages 57-61

   3. Trans-activation by hepatitis B virus X protein is mediated via a tumour promoter pathway

      • A. S. Kekulé, U. Lauer, L. Weiß, P. H. Hofschneider, R. Koshy

      Pages 63-64

   4. Truncated pre-S/S proteins transactivate multiple target sequences

      • G. Natoli, C. Balsano, M. L. Avantaggiati, E. De Marzio, M. Artini, D. Collepardo et al.

      Pages 65-69

   5. Hepatitis C virus and hepatocellular carcinoma

      • A. Sangiovanni, G. Covini, M. G. Rumi, R. Marcelli, M. Colombo

      Pages 70-75

   6. Prevalence of antibodies to hepatitis C virus in patients with hepatocellular carcinoma in Austria

      • Martina Baur, U. Hay, G. Novacek, C. Dittrich, P. Ferenci

      Pages 76-80

4. Hepatitis B virus variants

   1. Front Matter

      Pages 81-81

      PDF

Chronic viral hepatitis is discussed here in a multidisciplinary approach. The editors' goal was to assemble contributions from clinicians, laboratory physicians, epidemiologists, pathologists, and molecular biologists to provide a synopsis of all the important aspects of this disease. A key element in the chronic evolution of viral hepatitis is the persistent coexistence of a cytotoxic immune response and viral gene expression which is discussed in eleven articles on immune pathogenesis. The oncogenicity of hepatitis B virus at the molecular level and of hepatitis C virus at the epidemiological level is discussed in two chapters. The application of PCR for the detection of hepatitis viruses and their variants is a major topic of both practical and theoretical interest. The clinical significance of newly developed serological assays for diagnosis and prevention is discussed in depth by specialists from clinics, transfusion centers and virological laboratories. The therapy of chronic viral hepatitis is still unsatisfactory, but some slow progress is described in several articles. Furthermore, the volume has a special chapter on the often neglected topic of chronic hepatitis in childhood.

• Antigen
• HIV
• Interferon
• Radiologieinformationssystem
• Transplantation
• diagnosis
• epidemiological
• epidemiology
• infections
• prevention
• hepatology

• Titolare II Cattedra Clinica, Malattie Tropicli e Infettive, Roma, Italy

  C. Bac, G. Taliani

• Institut für Medizinische Virologie, Justus-Leibig-Universität, Giessen, Federal Republic of Germany

  W. H. Gerlich

Policies and ethics