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Table of contents (11 chapters)
Keywords
About this book
Insulin-like growth factors (IGFs), their binding proteins and their receptors play important roles in regulating growth, metabolism, proliferation and survival for many cells and tissues throughout lifespan in humans and other species. Circulating IGF1 is known to be an endocrine regulator, with metabolic effects related to, and partly convergent with, insulin signalling. IGF1 also mediates many of the growth promoting effects of GH, and there is an ongoing debate as to the relative contributions of endocrine-, vs locally-derived IGF1 for systemic growth. More recently however, it has become clear that IGFs may be key local growth and cellular survival factors for many different tissues, active from early in embryonic development, essential for normal maturation and growth during foetal life. IGFs continue to play important roles throughout adult life in many diverse processes such as tissue repair, cellular proliferation, tissue remodelling and metabolic regulation. IGF systems are tightly regulated; orderly control of cellular repair and metabolism is central to healthy ageing, whilst uncontrolled proliferation can lead to cancer.
Editors and Affiliations
Bibliographic Information
Book Title: IGFs:Local Repair and Survival Factors Throughout Life Span
Editors: David Clemmons, Iain C.A.F. Robinson, Yves Christen
Series Title: Research and Perspectives in Endocrine Interactions
DOI: https://doi.org/10.1007/978-3-642-04302-4
Publisher: Springer Berlin, Heidelberg
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2010
Hardcover ISBN: 978-3-642-04301-7Published: 03 December 2009
Softcover ISBN: 978-3-662-50583-0Published: 23 August 2016
eBook ISBN: 978-3-642-04302-4Published: 01 December 2009
Series ISSN: 1861-2253
Series E-ISSN: 1863-0685
Edition Number: 1
Number of Pages: XIII, 157
Topics: Endocrinology, Human Physiology, Gene Function