100 Years Since the Discovery of Human Blood Groups
Eibl, M., Mayr, W.R., Thorbecke, G.J. (Eds.)
2002, XX, 117 pp. 34 figs., 11 tabs.
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The contributors to this book highlight the scientific developments in the field of immunology concerning epitope recognition since the discovery by Karl Landsteiner. Karl Landsteiner ist best known for his discovery of the human blood groups. The revolutionary discoveries of this brilliant scientist in other fields have not received the recognition they deserve. His demonstration that poliomyelitis is transmissable showed the way for modern virology. His studies opening the field for epitope recognition, which he himself considered his main achievement, laid the foundation for research in our days.
Introduction.-Landsteiner in Vienna.-Antigen Recognition: 100 years after Landsteiner.-Induction and suppression of an autoimmune disease by oligomerized T cell epitopes: Enhanced in vivo potency of encephalitogenic peptides.-Determination of the expresssed T cell repertoire: The outcome of competition at the levels of antigen presentation and T cell receptor recognition.-Using monoclonal antibodies and site directed mutagenesis to map the epitopes of the blood group Rh D antigen.-Infections and the immune response to cardiac antigens.-Subject index