Pathophysiology of Headaches

1. Front Matter

   Pages i-x

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2. Anatomy of Headache

   • Hayrunnisa Bolay, Karl Messlinger, Mária Dux, Didem Akcali

   Pages 1-29

3. Animal Models of Migraine

   • Anna P. Andreou, Michael L. Oshinsky

   Pages 31-66

4. Animal Models of Tension-Type Headache and Trigeminal Autonomic Cephalalgias

   • Cristina Tassorelli, Rosaria Greco, Simon Akerman

   Pages 67-82

5. Genetics of Headache

   • Cherubino Di Lorenzo, Filippo M. Santorelli, Arn M. J. M. van den Maagdenberg

   Pages 83-99

6. Human Models of Primary Headaches

   • Henrik Winther Schytz, Guus G. Schoonman

   Pages 101-115

7. Imaging of Migraine

   • Michaela Andelova, David Borsook, Till Sprenger

   Pages 117-136

8. Imaging of Other Primary Headaches

   • Sarah Miller, Manjit S. Matharu

   Pages 137-153

9. Neurophysiology of Migraine

   • Gianluca Coppola, Francesco Pierelli, Petter M. Omland, Trond Sand

   Pages 155-174

10. Neurophysiology of Other Primary Headaches

    • Anna Ambrosini, Gianluca Coppola

    Pages 175-183

11. Biochemistry of Primary Headaches

    • Paola Sarchielli, Stefano Caproni, Cinzia Costa, Delia Szok, Janos Tajti

    Pages 185-215

12. Pathophysiology of Migraine: Current Status and Future Directions

    • Jakob Møller Hansen, Dan Levy

    Pages 217-234

13. Pathophysiology of TTH: Current Status and Future Directions

    • Sait Ashina, Lars Bendtsen

    Pages 235-246

14. Pathophysiology of Cluster Headache: Current Status and Future Directions

    • Mark Obermann, Manjit Matharu

    Pages 247-258

15. Pathophysiology of Medication Overuse Headache: Current Status and Future Directions

    • Signe Bruun Munksgaard, Frank Porreca

    Pages 259-272

This book provides a detailed overview of the current state of knowledge regarding the pathophysiology of both primary headaches – migraine, tension-type headache (TTH), and cluster headache – and the very important and frequent type of secondary headache, medication overuse headache (MOH). After an introductory chapter describing relevant neuroanatomy and vascular anatomy, the evidence gained from animal models regarding the pathophysiology of migraine and the other primary headaches is reviewed. Knowledge of the genetic component in the different types of headache is then examined with reference to recent evidence, for example regarding the implication of the trigeminovascular system and cortical spreading depression in migraine. Detailed information is provided on insights into primary headaches from imaging studies, including functional magnetic resonance imaging and positron emission tomography and on their neurophysiology and biochemistry. A further series of important chapters describe present knowledge of the pathophysiology of each specific type of headache and consider future directions. Written by acknowledged experts in their fields from Europe and the United States, clinicians and students will find Pathophysiology of Headaches to be an excellent source of up-to-date information on why patients experience headaches. In addition, it will be of value for pain researchers investigating the underlying mechanisms of headache.

• Biochemistry of headache
• Cluster headache
• Imaging of headache
• Medication overuse headache
• Neurophysiology of migraine
• Tension-type headache

“This is a superb reference on the anatomy and physiology of headache as currently understood and serves as a resource for researchers and clinicians who work with headache patients. The editors and authors provide an extremely well researched and organized book. … chapters are extraordinarily well organized, defining terms as the information is presented and moving into newer concepts in each chapter. … It is a tremendous addition to the store of knowledge in the research and treatment of headaches.” (Vincent F. Carr, Doody’s Book Reviews, July, 2015)

• Department of Neurology, Danish Headache Center Rigshospitalet and Glostrup Hospital, Glostrup, Denmark

  Messoud Ashina

• Department of Health Sciences, University of Florence, Florence, Italy

  Pierangelo Geppetti

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