Antiphospholipid Antibody Syndrome

1. Front Matter

   Pages i-x

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2. Genetics and Origin of Antiphospholipid Syndrome

   • Alessandra Soriano, Miri Blank, Yehuda Shoenfeld

   Pages 1-12

3. The Paradox of Lupus Anticoagulant

   • Alessandra Banzato, Vittorio Pengo

   Pages 13-23

4. Antiphospholipid Antibody Mechanisms of Thrombosis

   • Pier Luigi Meroni, Chiara Crotti, Cecilia Chighizola

   Pages 25-35

5. The Pathogenic Mechanisms for Antiphospholipid Antibodies (aPL)-Mediated Pregnancy Loss

   • Nicoletta Di Simone, Silvia D’Ippolito

   Pages 37-46

6. Classification Criteria for the Antiphospholipid Syndrome

   • Ronald H. W. M. Derksen, Ruth Fritsch-Stork

   Pages 47-59

7. Non-classification Criteria

   • Maria Gerosa, Francesca Rovelli

   Pages 61-74

8. Obstetric APS

   • Micaela Fredi, Angela Tincani

   Pages 75-87

9. APS and the Nervous System

   • Cecilia Beatrice Chighizola, Davide Sangalli, Barbara Corrà, Vincenzo Silani, Laura Adobbati

   Pages 89-102

10. Antiphospholipid Syndrome (APS) and the Renal Involvement

    • Nicoletta Mezzina, Renato Alberto Sinico

    Pages 103-112

11. Non-Thrombotic Hematologic Manifestations in APS

    • Wilma Barcellini, Carolina Artusi

    Pages 113-126

12. Heart and APS

    • Gentian Denas, Vittorio Pengo

    Pages 127-150

13. Skin Involvement in Antiphospholipid Syndrome

    • Angelo Valerio Marzano, Silvia Alberti Violetti, Riccardo Lazzari, Emilio Berti

    Pages 151-161

14. Additional Organs Involved in Antiphospholipid Syndrome: Eye, Ear-Nose-Throat, Lung, Gastroenteric System, Endocrine Glands

    • Maria De Santis, Angela Ceribelli, Carlo Selmi

    Pages 163-168

15. Differential Diagnosis

    • Domenico Prisco, Giacomo Emmi, Elena Silvestri, Lucia Ciucciarelli, Elena Niccolai, Mario Milco D’Elios et al.

    Pages 169-184

16. Treatment of Thrombosis in Antiphospholipid Syndrome

    • Simon Braham, Paolo Bucciarelli, Marco Moia

    Pages 185-192

17. Treatment of Pregnancy Complications

    • Barbara Acaia, Federica Rossi, Cecilia Beatrice Chighizola

    Pages 193-206

18. Antiphospholipid Antibody Carriers

    • Francesca Dall’Ara, Cecilia Nalli, Laura Andreoli

    Pages 207-218

19. New Treatments

    • Cecilia Beatrice Chighizola, Tania Ubiali

    Pages 219-232

20. Secondary Antiphospholipid Syndrome

    • Anisur Rahman, Maria Gabriella Raimondo

    Pages 233-248

This book, part of the series Rare Diseases of the Immune System, offers comprehensive, up-to-date coverage of the pathophysiology and management of the antiphospholipid syndrome (APS). Immunologic and genetic aspects are discussed and the pathogenic mechanisms responsible for such phenomena as APS-mediated thrombosis and pregnancy loss/complications are explained. The main clinical manifestations, classification criteria and diagnostic tools are identified, and close attention is paid to the nature of the involvement of various organs or organ systems in APS. Specific chapters describe the treatment of the different symptoms, therapies of value in avoiding recurrences, and innovative treatment approaches. The authors are senior experts in the field who are aided by younger fellows, ensuring that the book is also educationally oriented. This handy volume will be a valuable tool for postgraduates in training and professionals wishing to extend their knowledge of this specific syndrome.

• Antiphospholipid antibody syndrome
• Autoantibodies
• Hughes syndrome
• Phospholipid binding proteins
• Pregnancy complications
• Thrombosis

From the book reviews:

“The purpose is to provide an overview of this very difficult subject that will benefit bench researchers as well as bedside clinicians. The book would serve any audience who wants to know more about antiphospholipid syndrome. … This is an excellent, up-to-date overview of antiphospholipid syndrome. It will serve as a handy tool to get more information on the topic.” (Dany V. Thekkemuriyil, Doody’s Book Reviews, February, 2015)

• Department of Rheumatology, Gaetano Pini Institute, Milan, Italy

  Pier Luigi Meroni

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