Etiology of Acute Leukemias in Children

1. Front Matter

   Pages i-xiii

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2. Introduction: Childhood Leukemia

   • Aurora Medina-Sanson

   Pages 1-48

3. Etiology and Prevention of Acute Leukemias in Children

   • Juan Carlos Núñez-Enríquez, Janet Flores-Lujano, Vilma Carolina Bekker-Méndez, David Aldebarán Duarte-Rodríguez, Juan Manuel Mejía-Aranguré

   Pages 49-74

4. HTLV-1 as a Model for Identifying the Causes of Human Leukemia

   • José Arellano-Galindo, Luz María Rocha-Ramírez, Sergio Zavala-Vega, Elva Jiménez-Hernández, Juan Xicotencatl-Cortés, Sara Ochoa-Pérez et al.

   Pages 75-88

5. Etiology of Leukemia in Children with Down Syndrome

   • Ana C. Xavier, Yubin Ge, Jeffrey W. Taub

   Pages 89-108

6. Origin of Leukemia in Children with Down Syndrome

   • Johann K. Hitzler

   Pages 109-131

7. Model for the Origin of Acute Leukemias in Children: Interaction of Three Factors—Susceptibility, Exposure, and Window of Vulnerability

   • Juan Manuel Mejía-Aranguré

   Pages 133-155

8. Molecular Origin of Childhood Acute Lymphoblastic Leukemia

   • Esmé Waanders, Marjolijn C. J. Jongmans, Charles G. Mullighan

   Pages 157-206

9. Environmental Factors and Exposure Time Windows Related to the Etiology of Acute Lymphoblastic Leukemia in Children

   • Maria Luisa Pérez-Saldivar, A. Rangel-López, A. Fajardo-Gutiérrez, Juan Manuel Mejía-Aranguré

   Pages 207-290

10. Early Hematopoietic Differentiation in Acute Lymphoblastic Leukemia: The Interplay Between Leukemia-Initiating Cells and Abnormal Bone Marrow Microenvironment

    • Armando Vilchis-Ordoñez, Elisa Dorantes-Acosta, Eduardo Vadillo, Briceida López-Martínez, Rosana Pelayo

    Pages 291-318

11. Back Matter

    Pages 319-320

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Childhood acute leukemias are one of the main causes of death in children aged 1 to 14 years in some countries; and unfortunately, we have been unable to prevent it. Certainly, a good parcel of it is due to the poor understanding about its etiology. This book aims to describe the most important theories and hypothesis regarding childhood acute leukemia. Written by the most outstanding researchers in the field, this book intends to contribute to a greater understanding of the etiology of this disease. It goes beyond the simple and common analysis of risk factors, which hardly allows us to draw definite conclusions. By addressing the etiology of the disease, discussing from molecular biology until epidemiology and clinical manifestations, this book will guide present and future approaches, contributing for a better clinical management of leukemia in children. The knowledge regarding etiology is a crucial step for a better evaluation, prevention and treatment of a disease. Thus, this book finally intends to provide such knowledge, allowing physicians and practitioners to a better manage of childhood acute leukemias.

• Hemato-oncology
• Leukemia
• Pediatrics
• Child
• Cancer

“The purpose is to provide a broader view of the origins of childhood leukemia. … The target audience is professionals working in the area of diagnosis and treatment of childhood leukemia, such as epidemiologists, molecular biologists, cellular biologists, pediatricians, and hematologists/oncologists interested in the field of acute leukemia. … It is useful as a foundation for further discussion on the mechanisms by which these different factors interact to generate the ultimate result, acute leukemia.” (Joseph Rosenthal, Doody’s Book Reviews, July, 2016)

• Coordinación de Investigación en Salud, Instituto Mexicano del Seguro Social, City, Mexico

  Juan Manuel Mejía-Aranguré

Physician (1990), MSc in Epidemiology (1994) and PhD in Clinical Epidemiology (2004) by the Universidad Nacional Autónoma de México. Dr. Mejia-Arangure serves as researcher at the Pediatric Hospital, National Medical Center “Century XXI” of the Instituto Mexicano del Seguro Social. He has 24 years of experience in research; his interests include investigating the etiology of acute leukemias in children. Dr. Mejia-Arangure has published more than 60 scientific articles, 10 book chapters and one book on clinical epidemiology of acute lymphoblastic leukemia. He has been reviewer for different journals, i.e. BMC Cancer, BMC Immunology, European Journal of Cancer Prevention, American Journal of Preventive Medicine, Archives of Medical Research, BMJ Open, among others. Dr. Mejia-Arangure is also member of different International Societies and have received many Grants to support his research.

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