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Medicine - Internal Medicine | Liver Immunology - Principles and Practice

Liver Immunology

Principles and Practice

Gershwin, M. Eric, Vierling, John M., Manns, Michael P. (Eds.)

2nd ed. 2014, XVI, 480 p. 117 illus., 92 illus. in color.


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  • Thoroughly revised, updated and a comprehensively leading title in the field
  • Covers bacterial, parasitic and viral infections of the liver, autoimmune liver disease, alcoholic and non-alcoholic fatty liver diseases, as well as transplantation issues
  • Developed by an international panel of leading experts

Liver Immunology: Principles and Practice, Second Edition begins with important information about the epidemiology and mortality of liver disease worldwide. This information is followed by chapters related to basic immunology, application of liver immunology for diagnosis, and several excellent chapters that provide a solid foundation for understanding immune-mediated liver disease, including those associated with the biliary tree. A chapter on non-hepatic manifestations of immune mediated liver disease helps provide context for how these diseases affect the patient overall.  In addition, chapters discuss various discrete immunologically-mediated infectious liver disorders including those related to bacteria, parasites, and all of the classic viruses. Chapters on the traditional autoimmune liver diseases --  primary biliary cirrhosis, autoimmune hepatitis, primary sclerosing cholangitis as well as overlap syndrome – are also included. The breadth of this comprehensive second edition is highlighted by chapters on alcoholic liver disease, non-alcoholic fatty liver disease, and drug-induced liver disease, among others.  This invaluable new edition ends with a forward-looking view of future directions and how the field might meet the challenge of refractory patients.  Developed by a renowned group of authors, Liver Immunology: Principles and Practice, Second Edition will again serve as a comprehensive textbook by providing an excellent overview for this rapidly evolving field. It greatly adds to the understanding of the pathogenesis of these diseases, while also providing novel insights that can be harnessed into helping improve the care of patients afflicted with various immune-mediated diseases.  This volume will again be a must-read for clinicians at all levels, investigators and students.

Content Level » Professional/practitioner

Related subjects » Immunology - Internal Medicine

Table of contents 

Introductory Comments


About the authors


Preface            Meeting the Challenge of Patients with Immune Mediated Liver Disease

                        Keith D. Lindor, keith.lindor@asu.edu                                                          


Foreword:        Contemporary Liver Immunology and Immunopathology:  Obstacles and Opportunities

                        Ian R. Mackay, ian.mackay@monash.edu


Chapter 1:        Core concepts in immunology

                        Cliona O'Farrelly & Derek Doherty


Chapter 2:        The Geoepidemiology of Autoimmune Liver Disease            

Carlo Selmi, Cecilia B. Chighizola, Angela Ceribelli, Maria De Santis, Pier Luigi Meroni, & Renqian Zhong


Chapter 3:        Diagnostic Liver Immunology

                        Christopher Bowlus                                        


Chapter 4:        The Liver as a Lymphoid Organ

                        Percy Knolle


Chapter 5:        Innate Immunity and Disorders of the Liver    

Mathias Heikenwalder, Percy Knolle, & U. Protzer


Chapter 6:        The Liver and Immune Tolerance                                                      

                        Zhigang Tian, Cai Zhang, & Zhe-Xiong Lian


Chapter 7:        The Diagnosis and Classification of Immune Mediated Hepatic


                        F. Alvarez                                           


Chapter 8:        The Diagnosis and Classification of Immune Mediated Biliary Diseases     

                        Gideon Hirschfield




Chapter 9:        Bacterial Infections in Liver                                                                          

                        Eirini I. Rigopoulou, Daniel S. Smyk, Timoklia Orfanidou, Dimitrios Bogdanos, &

                        M. Eric Gershwin


Chapter 10:      The Diagnosis and Classification of Parasitic Diseases of the Liver              

                        Shyamapada Mandal & Manisha Mandal


Chapter 11:      Viral Diseases of the Liver

                        Gadi Lalazar & Yaron Ilan


Chapter 12:      Hepatitis A: Immune response and virus evolution                                       

                        Rosa M. Pinto, Albert Bosch, & Gerardo Kaplan


Chapter 13:      Immunopathogenesis of Chronic Hepatitis B and the Clinical                       

                        Events that Shape its Natural History                                                            

                        Stevan A. Gonzalez & Robert P. Perrillo


Chapter 14:      Hepatitis C                                                                                                     

                        Mario U. Mondelli, Stefania Varchetta, & Francesco Negro


Chapter 15:      Immunopathogenesis of Hepatitis D

Sebastian Luneman, Jan Grabowski, & Heiner Wedemeyer


Chapter 16:      Hepatitis E                                                                                         

                        Hiroki Takahashi & Mikio Zeniya


Chapter 17:      Primary Biliary Cirrhosis                                                                     

                        Pietro Invernizzi, Patrick S.C. Leung, Ma Xiong, & M. Eric Gershwin,


Chapter 18:      Autoimmune Hepatitis                                                                       

                        Diego Vergani, Rodrigo Liberal, & Giorgina Mieli-Vergani


Chapter 19:      Primary Sclerosing Cholangitis                                                                       

                        Harald Hofer, Emina Halibasic, Katharina Staufer & Michael Trauner,


Chapter 20:      Overlap Syndromes

                        Said Al Mamari, Roger Chapman & Kirsten Muri Boberg,


Chapter 21:      Alcoholic Liver Disease                                                                                 

                        Gyongyi Szabo


Chapter 22:      Non-Alcoholic Fatty Liver Disease                                                                

                        Arun Sanyal &             Vaishali Patel


Chapter 23:      Pediatric Liver Disease                                                                                   

                        Giorgina Mieli-Vergani, Rodrigo Liberal & Diego Vergani


Chapter 24:      Mechanisms of Acute Liver Failure                                                                

                        Christian Trautwein & Alexander Koch


Chapter 25:      Non-Immune Mediated Drug Induced Hepatotoxicity

                        Christian Strassburg


Chapter 26:      Immune-Mediated Drug Induced Liver Injury                                               

                        Einar S. Bjornsson & Guruprasad Aithal


Chapter 27:      The Immunopathogenesis of Cirrhosis                                               

                        Bin Gao, Scott L. Friedman & Wajahat Z. Mehal


Chapter 28:      Graft vs. Host Disease                                                                       

                        John Vierling & Ali Raza


Chapter 29:      Immune-mediated liver disease in the transplantated liver                

                        Palak Jitendrakumar Trivedi, Ka-Kit Li & James Neuberger,


Chapter 30:      The future of liver immunology

                        M. Eric Gershwin, John Vierling & Michael Manns


Distribution rights 

Distribution rights for India: CBS Publishers, New Delhi, India

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