Physiology and Physiopathology of Adipose Tissue

1. Front Matter

   Pages i-xix

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2. Adipose Tissue Development

   1. Front Matter

      Pages 1-1

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3. ADIPOSE TISSUE DEVELOPMENT

   1. Development of Adipose Cells

      • Tala Mohsen-Kanson, Brigitte Wdziekonski, Phi Villageois, Anne-Laure Hafner, Nadège Lay, Pauline Martin et al.

      Pages 3-16

   2. Emerging Roles of Cell Cycle Regulators in Adipocyte Metabolism

      • Carine Chavey, Sylviane Lagarrigue, Jean-Sébastien Annicotte, Lluis Fajas

      Pages 17-25

   3. Angiogenesis in Adipose Tissue

      • Anne Bouloumié, Jean Galitzky

      Pages 27-38

   4. Prospects for Using Adipose Tissue in Regenerative Medicine

      • Louis Casteilla, Valérie Planat-Benard, Patrick Laharrague, Béatrice Cousin, Anne Lorsignol

      Pages 39-49

   5. Brown Adipose Tissue: Function and Development

      • Daniel Ricquier

      Pages 51-66

   6. Histology of Adipose Tissue

      • Joan Tordjman

      Pages 67-75

4. Adipose Tissue Metabolic Functions

   1. Front Matter

      Pages 77-77

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5. ADIPOSE TISSUE METABOLIC FUNCTIONS

   1. Glucose Transport in White Adipocyte

      • Mireille Cormont, Vincent Kaddai

      Pages 79-99

   2. Mechanism of Storage and Synthesis of Fatty Acids and Triglycerides in White Adipocytes

      • Fabienne Foufelle, Pascal Ferré

      Pages 101-121

   3. Adipocyte Lipid Droplet Physiology

      • Isabelle Dugail, Soizic Le Lay

      Pages 123-139

   4. Adipose Tissue Lipolysis

      • Dominique Langin, Etienne Mouisel

      Pages 141-157

   5. The Adipose Tissue: Storage, Source, and Target of Pollutants

      • Robert Barouki, Karine Clément

      Pages 159-167

6. Endocrine Functions of Adipocyte

   1. Front Matter

      Pages 169-169

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7. ENDOCRINE FUNCTIONS OF ADIPOCYTE

   1. Chatting Between the Brain and White Adipose Tissues

      • Luc Pénicaud, Anne Lorsignol

      Pages 171-185

   2. Adiponectin: An Adipokine with Multiple Faces

      • Jean-Philippe Bastard, Camille Vatier, Bruno Fève

      Pages 187-200

   3. Apelin Metabolic Functions

      • Isabelle Castan-laurell, Cédric Dray, Claude Knauf, Philippe Valet

      Pages 201-211

   4. Up-to-Date on Novel “Adipocrines”

      • Christian Carpéné, Jean-Sébastien Saulnier-Blache

      Pages 213-227

8. Pathology of Adipose Tissue

   1. Front Matter

      Pages 229-229

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The scientific advances in the physiology and pathophysiology of adipose tissue over the last two decades have been considerable. Today, the cellular and molecular mechanisms of adipogenesis are well known. In addition, adipose tissue is now recognized as a real endocrine organ that produces hormones such as the leptin acting to regulate food intake and energy balance in the central nervous system, a finding that has completely revolutionized the paradigm of energy homeostasis. Other adipokines have now been described and these molecules are taking on increasing importance in physiology and pathophysiology. Moreover, numerous works have shown that in obesity, but also in cases of lipodystophy, adipose tissue was the site of a local low-grade inflammation that involves immune cells such as macrophages and certain populations of lymphocytes. This new information is an important step in the pathophysiology of both obesity and related metabolic and cardiovascular complications. Finally, it is a unique and original work focusing on adipose tissue, covering biology and pathology by investigating aspects of molecular and cellular biology, general, metabolic, genetic and genomic biochemistry.

• Adipocytes
• Adipokines
• Adipose tissue
• adipogenesis
• inflammation
• metabolic disease

From the reviews:

“This book comprehensively reviews our current understanding of adipose tissue biology as well as perturbations in adipose tissue that occur in pathological states such as obesity and diabetes. … This is an excellent resource for adipose tissue biologists and students in the field. … this book also may be useful to scientists in associated disciplines who are interested in understanding the ramifications of altered adipose tissue mass and function on many disease states. … a very credible resource for anyone interested in the field.” (Robert Michael Sargis, Doody's Book Reviews, March, 2013)

• Paris, France

  Jean-Philippe Bastard

• Hôpital Saint-Antoine, Paris, France

  Bruno Fève

Jean-Philippe Bastard is a researcher at Inserm Institute at Tenon Hospital in Paris, France and Vice-President of the AFERO, the French Society of Study and Research on Obesity. Bruno Fève is Professor of Endocrinology at the Saint-Antoine Hospital in Paris, France.

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