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Medicine - Internal Medicine | Physiology and Physiopathology of Adipose Tissue

Physiology and Physiopathology of Adipose Tissue

Bastard, Jean-Philippe, Fève, Bruno (Eds.)

2012, XX, 440 p.

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  • An original work focused on adipose tissue and different from other books dedicated to the topic of obesity
  • Teaching work intended both for teachers and students and researchers
  • An updated book with the recent and important discoveries in the field
The scientific advances in the physiology and pathophysiology of adipose tissue over the last two decades have been considerable. Today, the cellular and molecular mechanisms of adipogenesis are well known. In addition, adipose tissue is now recognized as a real endocrine organ that produces hormones such as the leptin acting to regulate food intake and energy balance in the central nervous system, a finding that has completely revolutionized the paradigm of energy homeostasis. Other adipokines have now been described and these molecules are taking on increasing importance in physiology and pathophysiology. Moreover, numerous works have shown that in obesity, but also in cases of lipodystophy, adipose tissue was the site of a local low-grade inflammation that involves immune cells such as macrophages and certain populations of lymphocytes. This new information is an important step in the pathophysiology of both obesity and related metabolic and cardiovascular complications. Finally, it is a unique and original work focusing on adipose tissue, covering biology and pathology by investigating aspects of molecular and cellular biology, general, metabolic, genetic and genomic biochemistry.

Content Level » Research

Keywords » Adipocytes - Adipokines - Adipose tissue - adipogenesis - inflammation

Related subjects » Internal Medicine - Life Sciences

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