Diamanti-Kandarakis, Evanthia, Gore, Andrea C. (Eds.)
2012, XVIII, 378 p.
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First text to focus exclusively on the effects of endocrine disruptors in regard to puberty
Comprehensive, covering basic biology of endocrine disruptors through definition and classification of endocrine disruptors, physicochemical properties, environmental distribution, and clinical consequences
Discusses molecular mechanisms of endocrine disruption and endocrine disruptors in the developing organism including the neuroendocrine hypothalamic-pituitary-gonadal targets of developmental exposure to endocrine disruptors
Addresses developmental exposure to endocrine disruptors and consequent adverse female and male reproductive outcomes
Details developmental exposure of endocrine disruptors on thyroid dysregulation and on metabolism, as well as key issues involved in the way endocrine disruptors are discussed in the public health arena
Endocrine disruption represents one of the most controversial environmental issues of our time. Mounting evidence stemming from more than 10 years of experimental, epidemiological and clinical studies has transformed the once generally discounted subject of endocrine disruptors into an issue of tremendous concern not only within the scientific community but among society as a whole. Following initial evidence from basic research, endocrine disruption in humans has now emerged as a major medical challenge. In this respect, puberty, a crucial developmental stage, has been definitively identified as a key window of vulnerability with regard to endocrine disruptors. Written by leading authorities in the field, Endocrine Disruptors and Puberty offers an engaging and comprehensive overview of this fascinating and rapidly growing problem. An indispensable resource for all clinicians and scientists interested in this challenging endocrinologic topic, Endocrine Disruptors and Puberty is a timely contribution that will help navigate a path toward understanding the problem and developing solutions.
Content Level »Professional/practitioner
Keywords »Adipocyte - Birth weight - Body weight - Breast development - Childhood - Development - Endocrine disruption - Endocrine disruption and Male:Female Ratio - Endocrine disruption and population risk - Endocrine disruption and public health - Endocrine disruptors - Enviromental - Mammary gland - Metabolism - Neuroendocrine HPG - Ovarian function - Pancreatic function - Polychlorinated biphenyls - Premature - Prostate - Puberty - Puberty timing - Reproductive tract abnormalities - Testicular development - Thyroid dysregulation - Urogenital tract malformation