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Cushing's Syndrome

Pathophysiology, Diagnosis and Treatment

  • Book
  • © 2011

Overview

Editors:
  1. Marcello D. Bronstein

    1. , Division of Endocrinology and Metabolism, Hospital das Clínicas, University of Sao, Sao Paulo, Brazil

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  • Provides up to date information on various strategies to establish the diagnosis of Cushing’s syndrome
  • Approaches to the differential diagnosis and specific treatments for each condition are provided
  • Chapters discuss controversies in diagnosis and differential diagnosis provide a nuanced perspective of these areas
  • Includes supplementary material: sn.pub/extras

Part of the book series: Contemporary Endocrinology (COE)

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Table of contents (23 chapters)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Physiology and Pathophysiology of the HPA Axis

    • Margaret Castro, Lucila Leico Elias, Paula Conde Lamparelli Elias, Ayrton Custodio Moreira
    Pages 1-20

  3. Etiologies of Cushing’s Syndrome

    • John Newell-Price
    Pages 21-29

  4. Pathogenesis of Corticotropic Tumors

    • Anat Ben-Shlomo, Ning-Ai Liu, Shlomo Melmed
    Pages 31-40

  5. Pathogenesis of Adrenocortical Tumors

    • Madson Q. Almeida, Emilia M. Pinto, Ana Claudia Latronico
    Pages 41-52

  6. Clinical Features of Cushing’s Syndrome

    • Oscar D. Bruno
    Pages 53-64

  7. Laboratorial Diagnosis of Cushing’s Syndrome: Differential Diagnosis with Pseudo Cushing’s Conditions as Obesity, Alcoholism and Depression

    • Martina De Martin, Francesca Pecori Giraldi, Francesco Cavagnini
    Pages 65-78

  8. Laboratorial Diagnosis of Cushing’s Syndrome: Differential Diagnosis Among the Different Causes of ACTH-Dependent and ACTH-Independent Cushing’s Syndrome

    • Antonio M. Lerário, Marcello D. Bronstein
    Pages 79-89

  9. Imaging for the Differential Diagnosis of Cushing’s Syndrome: MRI, CT, and Isotopic Scanning

    • Wouter W. de Herder, Richard A. Feelders
    Pages 91-103

  10. Inferior Petrosal Sampling for the Differential Diagnosis of ACTH-Dependent Cushing’s Syndrome

    • Bradley R. Javorsky, James W. Findling
    Pages 105-119

  11. The Surgical Management of Cushing’s Disease

    • Ian F. Dunn, Edward R. Laws Jr
    Pages 121-129

  12. Adrenal-Directed Treatment Options for Cushing’s Disease

    • William F. Young Jr., Geoffrey B. Thompson
    Pages 131-137

  13. Radiation Therapy and Stereotactic Radiosurgery for Cushing’s Disease

    • Jay Jagannathan, Edward R. Laws, Jason P. Sheehan
    Pages 139-149

  14. Medical Management of Cushing’s Syndrome

    • Cuong Dang, Peter J. Trainer
    Pages 151-162

  15. ACTH-Dependent Cushing Syndrome: Clinical and Diagnostic Aspects, and Treatment Approaches for Ectopic Cushing’s Syndrome

    • Krystallenia I. Alexandraki, Andrea M. Isidori, Ashley B. Grossman
    Pages 163-176

  16. Revisiting the Nelson’s Syndrome: Corticotroph Tumor Progression After Bilateral Adrenalectomy in Cushing’s Disease

    • Guillaume Assie, Laurence Guignat, Jérôme Bertherat, Xavier Bertagna
    Pages 177-187

  17. ACTH-Independent Cushing’s Syndrome: Adrenocortical Tumors

    • Maria Candida Barisson Villares Fragoso, Sorahia Domenice, Ana Claudia Latronico, Berenice Bilharinho Mendonca
    Pages 189-208

  18. ACTH-Independent Cushing’s Syndrome: Bilateral Macronodular Hyperplasia

    • Isabelle Bourdeau, Antoine Lampron, Tânia Longo Mazzuco, André Lacroix
    Pages 209-224

  19. ACTH-Independent Cushing’s Syndrome: Primary Pigmented Nodular Adrenal Disease in the Context of Carney’s Complex

    • Constantine Stratakis
    Pages 225-234

  20. Glucocorticoid Resistance

    • Elisabeth F. C. van Rossum, Steven W. J. Lamberts
    Pages 235-248
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Keywords

About this book

Cushing´s syndrome is a relatively rare clinical disorder that is associated with many co-morbidities such as systemic hypertension, diabetes, osteoporosis, impaired immune function and growth impairment in children, all of which severely reduce quality of life and life expectancy. Cushing’s Syndrome: Pathophysiology, Diagnosis and Treatment reviews the difficulties in distinguishing Cushing’s syndrome from these and other common conditions, such as central obesity, menstrual irregularity and depression. It also provides state-of-the-art information on various strategies to establish the diagnosis of Cushing’s syndrome and the differential diagnosis among its diverse etiologies, as well as therapeutic approaches. Additionally, a range of conditions that represent challenges for the diagnosis and treatment--such as renal failure, pediatric age, cyclic hypercortisolism, and pregnancy--are covered in detail. A valuable resource not only for endocrinologists but also internal medicine physicians, gynecologists, pediatricians, , pituitary surgeons and urologists, Cushing’s Syndrome: Pathophysiology, Diagnosis and Treatment provides insights by experts that will help all physicians dealing with Cushing´s syndrome to expand their knowledge about the condition and provide targeted, comprehensive care.

Reviews

From the reviews:

“This book contains 23 chapters written by 56 carefully selected experts from three continents. There are special chapters on physiology and pathophysiology of hypothalamic-pituitary-adrenal system as well as on the etiology of Cushing’s syndrome. … Several chapters deal in detail with surgical management, adrenal directed treatment, radiation therapy and medical management. … this book gives outstanding knowledge and is enriching the contemporaneous status of art on Cushing’s syndrome.” (Endocrine Regulations, January, 2012)

“Part of the Contemporary Endocrinology series, a very comprehensive treatise on this difficult to diagnose and treat to disease. Written by multidisciplinary scientists from several countries, it reviews in 23 chapters the physiology and pathophysiology of the HPA axis, the etiology and clinical features of Cushing’s syndrome (CS), diagnostic methods and problems, the various methods of treatment and differential diagnosis including ACTH independent CS. … Clearly written and highly illustrated … . Recommended.” (Pediatric Endocrinology Reviews (PER), Vol. 9 (2), December, 2011)

Editors and Affiliations

  • , Division of Endocrinology and Metabolism, Hospital das Clínicas, University of Sao, Sao Paulo, Brazil

    Marcello D. Bronstein

Bibliographic Information

  • Book Title: Cushing's Syndrome

  • Book Subtitle: Pathophysiology, Diagnosis and Treatment

  • Editors: Marcello D. Bronstein

  • Series Title: Contemporary Endocrinology

  • DOI: https://doi.org/10.1007/978-1-60327-449-4

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Science+Business Media, LLC 2011

  • Hardcover ISBN: 978-1-60327-448-7Published: 01 October 2010

  • Softcover ISBN: 978-1-61779-709-5Published: 03 December 2012

  • eBook ISBN: 978-1-60327-449-4Published: 01 October 2010

  • Series ISSN: 2523-3785

  • Series E-ISSN: 2523-3793

  • Edition Number: 1

  • Number of Pages: XII, 304

  • Topics: Endocrinology, Internal Medicine, Oncology, Pediatrics, Gynecology, Neurosurgery

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