IGF and Nutrition in Health and Disease

1. Front Matter

   Pages i-xxi

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2. Overview

   1. Front Matter

      Pages 1-1

      PDF

   2. Overview and Molecular Aspects of the Insulin-Like Growth Factor System

      • Martin L. Adamo, Lai Wang, Lisa Heron, Dalit Ben-Yosef, Hong Zhao, Derek Le Roith

      Pages 3-22

3. IGF and Nutritional Status

   1. Front Matter

      Pages 23-23

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   2. Regulation of Insulin-Like Growth Factor-I by Nutrition

      • Jean-Paul Thissen, Véronique Beauloye, Jean-Marie Ketelslegers, Louis E. Underwood

      Pages 25-52

   3. Nutrition and IGF Proteins in Chronic Malnutrition and Critical Illness

      • Pei-Ra Ling, Bruce R. Bistrian

      Pages 53-74

   4. The Insulin-Like Growth Factors and Assessment of Nutritional Status

      • M. Sue Houston

      Pages 75-103

4. Growth and Development

   1. Front Matter

      Pages 105-105

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   2. Regulation of Growth and the Insulin Growth Factor System by Zinc

      • Ruth S. MacDonald

      Pages 107-120

   3. The Role of the Insulin-Like Growth Factor System in Pre- and Postnatal Growth, Development, and Tumorigenesis

      • Charles T. Roberts Jr.

      Pages 121-132

   4. The Insulin-Like Growth Factor Axis in the Fetus and Neonate

      • Cynthia L. Blanco, Robert J. Ferry Jr.

      Pages 133-143

   5. Nutrition and the IGF System in Reproduction

      • Frank A. Simmen, Inseok Kwak, Jason L. Blum, Rosalia C. M. Simmen

      Pages 145-155

   6. The Insulin Growth Factor System and Nutrition in Adulthood and Aging

      • Moira S. Lewitt, Kerstin Hall

      Pages 157-174

5. IGF and Organ Systems

   1. Front Matter

      Pages 175-175

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   2. Nutrition and Insulin Growth Factor-I in Relation to Bone Health and Disease

      • Jean-Philippe Bonjour, Patrick Ammann, Thierry Chevalley, René Rizzoli

      Pages 177-192

   3. Effect of Insulin-Like Growth Factor Proteins on Skeletal Muscle Protein Metabolism During Normal and Catabolic Conditions

      • Charles H. Lang, Robert A. Frost

      Pages 193-209

   4. Insulin-Like Growth Factors and Nervous System Disorders

      • Gary Meyer, Aparna Bole, Eva L. Feldman

      Pages 211-225

   5. The Kidney and the Insulin-Like Growth Factor System in Health and Disease

      • Ralph Rabkin, Steven S. Guest, Franz Schaefer

      Pages 227-247

6. IGF in Disease States

   1. Front Matter

      Pages 249-249

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   2. The IGF and IGFBP System in Insulin Resistance and Diabetes Mellitus

      • Kerstin Brismar, Moira S. Lewitt

      Pages 251-270

A benchmark review on how specific nutrients or adverse nutritional states impact the components of the IGF (Insulin-like Growth Factor) system and affect human health and disease. The authors describe the fundamentals of the IGF system, explain its basic mechanisms of action, illuminate its essential role in physical development across the life span, and highlight the link between normal and abnormal cellular growth resulting in tumor formation. They also fully examine the clinical aspects of nutrition and IGF, from pre- and postnatal development through old age, in the maintenance of normal metabolism, bone, and muscle health, and their role in pathological states. Special attention is given to critical illness, diabetes, gastrointestinal diseases, kidney failure, endocrine dysfunctions, cardiovascular disease, neurological disorders, and cancer, as well as to their potential for IGF therapy.

• Diabetes
• Diabetes mellitus
• Insulin
• Malnutrition
• Nutrition
• bone health
• cancer
• growth factor
• insulin-like
• metabolism

From the reviews:

"This book provides a comprehensive and up-to-date review of the IGF system with respect to its role in nutritional health, development, and certain disease states...a comprehensive text that can be used by both the clinical and basic research community, and it emphasizes the IGF system with regard to overall nutritional health." - Doody's Health Sciences Book Review Journal

"This is a collection of 18 chapters on the insulin-like growth factor (IGF) system and nutrition, each worthy of attention. The book is thoughtfully organized into five major sections. … In summary, this is a significant book that carefully explores and shapes a better understanding of nutrition in health and disease. It is an excellent resource, deserving of a place at all reference libraries and for everyone involved with nutrition care and research." (James C. M. Chan, Pediatric Nephrology, April, 2006)

• Food and Nutrition Program, School of Family and Consumer, Bowling Green State University, Bowling Green, USA

  M. Sue Houston

• Division of Surgery, Department of Hospital Medicine, Bristol Royal Infirmary, Bristol, UK

  Jeffrey M. P. Holly

• JDRF Center for the Study of Complications in Diabetes, Department of Neurology, University of Michigan, Ann Arbor, USA

  Eva L. Feldman

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