Enteric Infections and Immunity

1. Front Matter

   Pages i-xix

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2. Indigenous Microorganisms as a Host Defense

   • Kenneth H. Wilson

   Pages 1-14

3. Mucosal Immunity

   • David W. Pascual, Hiroshi Kiyono, Jerry R. McGhee

   Pages 15-35

4. Vibrio cholerae

   • Matthew K. Waldor, John J. Mekalanos

   Pages 37-56

5. Immunity to Salmonella Infections

   • Toby K. Eisenstein, Duan Huang, Martin G. Schwacha

   Pages 57-78

6. Shigella Infection

   • Gerald T. Keusch, David W. K. Acheson

   Pages 79-100

7. Escherichia coli

   • Ronald P. Rabinowitz, Michael S. Donnenberg

   Pages 101-131

8. Molecular Pathogenesis of Campylobacter jejuni Enteritis

   • Michael E. Konkel, Witold Cieplak Jr.

   Pages 133-147

9. Clostridia and Bacteroides in Enteric Infections

   • David M. Lyerly, Roger L. van Tassell, Tracy D. Wilkins

   Pages 149-167

10. The Staphylococcal Toxins in Human Disease

    • Merlin S. Bergdoll

    Pages 169-185

11. Immunological Aspects of Viral Gastroenteritis

    • Shunzo Chiba

    Pages 187-206

12. Immunopathogenesis of Entamoeba histolytica

    • Sergio Arias-Negrete, Kris Chadee

    Pages 207-226

13. Giardia Infections

    • Martin F. Heyworth

    Pages 227-238

14. The Immune Regulation of Intestinal Helminthiases

    • Robert M. Genta

    Pages 239-256

15. Back Matter

    Pages 257-272

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As we approach the end of this millennium, enteric diseases remain impor­ tant public health problems. In many parts of the world, sanitary measures have advanced little over the last century, although some of the governments in those areas are striving to improve facilities for sanitation and to educate their people in proper handling of food, water, sewage, and other modes of transmission of pathogenic microbes. Even in highly developed countries, outbreaks of diarrheal diseases occur today. Globally, the annual morbidity from enteric infections is estimated at several billion and deaths at several million per year. In this volume, descriptions of some of these diseases, of immunity that results from them, of clinical studies that promote under­ standing of individual and community immunity, of molecular factors of pathogenesis, and/or of advances in vaccine development have been pro­ vided by leading researchers. At present, the application of molecular methods is enhancing the identification of protective antigens of many microorganisms. In addition, new methods for design and delivery of vac­ cines are being devised. Perhaps then more effective tools for reducing at least some of these diseases will be available within the next decade. Lois J. Paradise Herman Friedman Mauro Bendinelli vii Contents Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xv LOIS J. PARADISE 1. Indigenous Microorganisms as a Host Defense 1 KENNETH H. WILSON 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. Composition of Intestinal Biota. . . . . . . . . . . . . . . . . . . . . . . . 2 3. Molecular Approaches to Determine Composition of the Biota . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . 3 4. Role of the Host in Determining the Composition of the Biota . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

• Pathogene
• biology
• cell
• cytokines
• development
• forest
• gastroenterology
• immunology
• infection
• microbiology
• microorganism
• pathogenesis
• toxin
• vaccine
• hepatology

`This book serves as a concentrated point of reference for a globally important group of infections.'
Doody's

• University of South Florida College of Medicine, Tampa, USA

  Lois J. Paradise, Herman Friedman

• University of Pisa, Pisa, Italy

  Mauro Bendinelli

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