Overview
- Editors:
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Mauro Bendinelli
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University of Pisa, Pisa, Italy
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Herman Friedman
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University of South Florida, Tampa, USA
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Table of contents (22 chapters)
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- Richard L. Crowell, Burton J. Landau, Kuo-Hom Lee Hsu, Maggie Schultz
Pages 51-63
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- Ferdinando Dianzani, Maria R. Capobianchi, Donatella Matteucci, Mauro Bendinelli
Pages 65-80
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- Mauro Bendinelli, Pier Giulio Conaldi, Donatella Matteucci
Pages 81-102
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- David P. Schnurr, Nathalie J. Schmidt
Pages 181-201
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- Norman R. Grist, Daniel Reid
Pages 221-239
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- Milagros P. Reyes, A. Martin Lerner
Pages 253-270
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- Kirk W. Beisel, Noel R. Rose
Pages 271-292
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- Eleanor J. Bell, Fakhry Assaad, Karin Esteves
Pages 319-337
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- Giovanni Rocchi, Antonio Volpi
Pages 339-349
About this book
It is now just 40 years since coxsackieviruses were first isolated by Dalldorf and Sickles in the "eponymous" town of Coxsackie, New York. Yet the overall contribution of coxsackieviruses to clinically evident dis ease of humans is still largely an open problem. Following their discov ery, coxsackieviruses were under intense clinical and laboratory scrutiny for a long time. Because of their relationship to polioviruses, the under standing of their structure, biochemistry, biology, and epidemiology ad vanced rapidly as a result of the formidable efforts that eventually led to the defeat of poliomyelitis. The ability of these viruses to infect mice permitted dissection of their pathogenicity in an experimental host and elucidation of conditions that influence its expression. Coxsackieviruses have been progressively associated with an increasing array of widely diverse human diseases. However, only some of the suggested causal correlations have been substantiated with satisfactory certainty. For others, conclusive evidence has so far resisted investigation. Most impor tant, among the latter are chronic maladies, such as dilated car diomyopathy and juvenile diabetes, that demand consideration. In recent times, there has been a partial eclipse of the subject of coxsackieviruses in the medical literature. In addition to the difficulties encountered in pinpointing their pathogenic potential, possible reasons include the general decline of interest in enteroviruses, which ensued after the conquest of poliomyelitis, and the continuous appearance in the limelight of new, more esoteric, and therefore more "appealing" viruses.
Editors and Affiliations
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University of Pisa, Pisa, Italy
Mauro Bendinelli
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University of South Florida, Tampa, USA
Herman Friedman
