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Cardiac Remodeling

Molecular Mechanisms

  • Book
  • © 2013

Overview

Editors:
  1. Bodh I. Jugdutt

    1. Walter MacKenzie Health Sciences Centre, Division of Cardiology, University of Alberta, Edmonton, Canada

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    You can also search for this editor in PubMed   Google Scholar

  2. Naranjan S. Dhalla

    1. St. Boniface General Hospital Research C, Institute of Cardiovascular Sciences, Winnipeg, Canada

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • First research-oriented volume to bring together diverse translational research and scattered information on heart failure
  • Summarizes major research advances in molecular, biochemical and translational aspects of cardiac remodeling over recent decades
  • Highlights areas needing further study, from key molecules and pathways to novel strategies
  • Includes supplementary material: sn.pub/extras

Part of the book series: Advances in Biochemistry in Health and Disease (ABHD)

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Table of contents (30 chapters)

  1. Front Matter

    Pages i-xi
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  2. Molecular Mechanisms of Remodeling in Pressure and Volume Overload Hypertrophy and Heart Failure

    1. Front Matter

      Pages 1-1
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    2. β-Adrenergic Receptor Signaling in Heart Failure

      • Grace Jung Ah Lee, Lin Yan, Dorothy E. Vatner, Stephen F. Vatner
      Pages 3-30

    3. Remodeling of Potassium Channels in Cardiac Hypertrophy

      • Tetsuo Sasano, Junko Kurokawa
      Pages 31-45

    4. Role of Gender in Ca2+ Cycling and Cardiac Remodeling Due to Heart Failure

      • Naranjan S. Dhalla, Amrit Malik, Shelly Zieroth, Paramjit S. Tappia
      Pages 47-64

    5. The Failing Heart: Is It an Inefficient Engine or an Engine Out of Fuel?

      • Waleed G. T. Masoud, Alexander S. Clanachan, Gary D. Lopaschuk
      Pages 65-84

    6. Regulation of Cardiac Hypertrophic Remodeling by the USP15/SLIM1 Pathway

      • Hiroto Nakajima
      Pages 85-96

    7. Role of Galectin-3 Pathways in the Pathogenesis of Cardiac Remodeling and Heart Failure

      • Lili Yu, Rudolf A. de Boer
      Pages 97-111

    8. A Mitochondriocentric Pathway to Cardiomyocyte Necrosis: An Upstream Molecular Mechanism in Myocardial Fibrosis

      • Adedayo A. Adeboye, Kevin P. Newman, Dwight A. Dishmon, Shadwan Alsafwah, Syamal K. Bhattacharya, Karl T. Weber
      Pages 113-125

    9. The ACE2/Ang (1–7) Pathway in Cardiac Remodeling Due to Pressure Overload

      • Seyyed M. R. Kazemi-Bajestani, Vaibhav B. Patel, Wang Wang, Gavin Y. Oudit
      Pages 127-139

    10. Local Actions of Natriuretic Peptides and Nitric Oxide in Cardiac Remodeling: Implications for Therapy

      • Michaela Kuhn, Hitoshi Nakagawa
      Pages 141-158

    11. Modulating G Protein-Coupled Receptors to Effect Reverse Cardiac Remodeling

      • Cinzia Perrino, Howard A. Rockman
      Pages 159-177

    12. Role of Inflammation and Matrix Proteinases in Cardiac Remodeling Following Stress and Injury

      • Davy Vanhoutte, Stephane Heymans
      Pages 179-200

    13. Role of Chymase in Matrix and Myocardial Remodeling Due to Mitral Regurgitation: Implications for Therapy

      • Spencer J. Melby, Carlos M. Ferrario, Chih-Cheng Wei, Louis J. Dell’Italia
      Pages 201-214

    14. Cardiac Remodeling Due to Aortic Regurgitation and Mitral Regurgitation

      • Blase A. Carabello
      Pages 215-226

    15. Reducing Oxidative Stress and Manipulating Molecular Signaling Events Using Resveratrol as a Therapy for Pathological Cardiac Hypertrophy

      • Shereen M. Hamza, Miranda M. Sung, Jason R. B. Dyck
      Pages 227-254

    16. Angiogenesis, Arteriogenesis, and Mitochondrial Dysfunction

      • M. S. McMurtry
      Pages 255-272

  3. Molecular Mechanisms of Remodeling After Myocardial Injury and Infarction

    1. Front Matter

      Pages 273-273
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    2. Subcellular Remodeling and Cardiac Dysfunction Due to Ischemia–Reperfusion Injury

      • Naranjan S. Dhalla, Vijayan Elimban, Larry Hryshko, Darren H. Freed
      Pages 275-291

    3. Role of MicroRNAs in Cardiac Hypertrophy and Postinfarction Remodeling

      • Jian Ding, Da-Zhi Wang
      Pages 293-311
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Keywords

About this book

The main objective of Cardiac Remodeling: Molecular Mechanisms is to summarize the major research advances in molecular, biochemical and translational aspects of cardiac remodeling over the last 2 to 3 decades under one cover and touch on future directions. It provides a high profile and valuable publication resource on molecular mechanisms of cardiac remodeling for both the present and future generations of researchers, teachers, students and trainees. This book should stimulate future translational research targeted towards discovery and development for preventing, limiting and reversing bad remodeling over the next few decades, with the ultimate goal of preventing progression to systolic and/or diastolic heart failure. The chapters suggest potential novel strategies that should receive attention for translating basic research knowledge to application in patients at the bedside.

Editors and Affiliations

  • Walter MacKenzie Health Sciences Centre, Division of Cardiology, University of Alberta, Edmonton, Canada

    Bodh I. Jugdutt

  • St. Boniface General Hospital Research C, Institute of Cardiovascular Sciences, Winnipeg, Canada

    Naranjan S. Dhalla

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