Genetics of Diabetes Mellitus

1. Front Matter

   Pages i-vii

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2. Genetics of Complex Diseases

   • Steven H. Nye, Soumitra Ghosh

   Pages 1-23

3. Genetic Factors in Type 1 Diabetes

   • Alberto Pugliese

   Pages 25-42

4. Type 1 Diabetes, Autoimmunity, and the MHC

   • Pamela R. Fain, George S. Eisenbarth

   Pages 43-64

5. The Insulin VNTR in the Genetics of Type 1 Diabetes

   • Constantin Polychronakos, Alberto Pugliese

   Pages 65-77

6. Maturity Onset Diabetes of the Young (Mody)

   • Philippe Froguel, Gilberto Velho

   Pages 79-89

7. Genetics of Mitochondria-Related Forms of Syndromic Diabetes Mellitus

   • Sabine Hofmann, Matthias F. Bauer, Klaus-Dieter Gerbitz

   Pages 91-108

8. Regulation of Insulin Secretion in Vivo

   • Josep Vidal, Steven E. Kahn

   Pages 109-131

9. The Molecular Basis of Insulin Action and Insulin Resistance

   • Joseph Avruch

   Pages 133-190

10. Mouse Models of Type 2 Diabetes

    • Domenico Accili, Byung-Chul Park

    Pages 191-205

11. Candidate Genes for Type 2 Diabetes

    • William L. Lowe Jr.

    Pages 207-230

12. Use of Genome Scans to Identify Susceptibility Genes for Type 2 Diabetes

    • Wen-Chi Hsueh, Braxton D. Mitchell, Alan R. Shuldiner

    Pages 231-250

13. Back Matter

    Pages 251-255

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Genetics of Diabetes Mellitus is intended to be a resource for both researchers in the field as well as endocrinologists, diabetologists, and geneticists who seek to learn more about this rapidly changing and important field. The text contains chapters from experts in the area who review aspects of the genetics of both type 1 and 2 diabetes mellitus as well as various syndromic forms of diabetes. The chapters are approachable for those who are not experts in the field of genetics but also comprehensive, so as to serve as an important resource for researchers interested in the genetics of diabetes mellitus.
A description of basic concepts of the genetics of complex diseases like type 1 and type 2 diabetes is provided as background. Type 1 diabetes is addressed in chapters exploring genetic determinants that affect the autoimmune process characteristic of type 1 diabetes, the role of the insulin gene in the pathogenesis of type 1 diabetes and additional genes that may impact upon the risk of type 1 diabetes. The impact of genetic determinants on the pathophysiology of type 2 diabetes is covered, as are chapters that address specific genes that are important for the development of type 2 diabetes. Finally, syndromic forms of diabetes, including Maturity Onset Diabetes of the Young and mitochondrial diabetes, and the insight that these disorders provide into more common forms of diabetes are reviewed.
Thus, this comprehensive and up-to-date text will serve as an important resource for those actively engaged in research in this area and clinicians treating these patients to provide an up-to-date entrée for those seeking to become more knowledgeable in the area.

• Diabetes
• Diabetes mellitus
• genes
• genetics
• insulin
• insulin resistance

• Northwestern University Medical School, Chicago, USA

  William L. Lowe

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