HIV and Liver Disease

Liver disease has been identified as a leading cause of death in HIV-infected patients since the introduction of highly active antiretroviral therapy (HAART) in 1996. The HIV treatment community has been caught largely unaware of this emerging dilemma. Many HIV care providers are ill-equipped to understand and interpret liver injury patterns, or to provide comprehensive care and management for viral coinfections which they are not familiar with.

HIV and Liver Disease provides a comprehensive update of the field covering the epidemiology, pathogenesis, management and treatment of liver disease in patients with HIV infection. The volume will help HIV care providers understand and interpret liver injury patterns, and/or provide comprehensive care and management for viral coinfections. Gastroenterologists and hepatologists will gain an understanding of complex drug regimens that are used to treat HIV and which may impact HCV and HBV treatment. Written by expert clinicians and researchers across multiple disciplines, HIV and Liver Disease will be of great value to gastroenterologists, hepatologists, infectious disease practitioners, as well as other health care providers who provide care or participate in research in the field of HIV.

• ART Hepatoxicity
• HAART
• HBV treatment
• HCV treatment
• antiretroviral therapy
• hepatic toxicity
• hepatology

From the book reviews:

“There are 22 chapters, each addressing a different topic regarding the association between human immunodeficiency virus (HIV) and liver disease. … The book is successful in providing an overview of liver disease in the context of HIV infection; it could be useful as part of a medical library or for selected physicians with a special interest in hepatology and HIV for contemplation, reference, and teaching purposes.” (Catherine Diamond, Clinical Infectious Diseases, April, 2013)

“HIV and Liver Disease is well timed, because many patients coinfected with HIV and HCV have effective, stable control of their HIV but have not been so fortunate in controlling their HCV. The text can be appreciated by a wide audience … most stimulating are the reviews describing the immunophysiology of the liver, with this organ functioning as ‘Grand Central Station’ for the antigen traffic from the portal vein resulting from disrupted intestinal epithelial integrity.” (Thomas Monson, Journal of the American Medical Association, Vol. 308 (4), July, 2012)

“In describing the close and growing relationship between HIV infection and liver disease, this book stresses the epidemiology and pathogenesis of liver disease in HIV and the mechanisms of coinfection with hepatitis viruses, with some chapters on the practical aspects of prevention and treatment. … The author targets a broad audience of all healthcare practitioners involved in the care of HIV patients as well as specialists. Students and people interested in the mechanisms of disease, immunopathogenesis, will find this fascinating.” (Cezarina Mindru, Doody’s Review Service, March, 2012)

• College of Medicine, Dept. Internal Medicine, University of Cincinnati, Cincinnati, USA

  Kenneth E. Sherman

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